Diätetik und Arteriosklerose pp 493-499 | Cite as
Interleukin 6-Freisetzung durch humane glatte Gefäßmuskelzellen
Chapter
Zusammenfassung
I mmunologischen, zytokinvermittelten Prozessen wird eine wichtige Rolle bei der Atherogenese zugeordnet. Neben Makrophagen, Endothelzellen und T-Lymphozyten sind auch glatte Gefäßmuskelzellen in der Lage, zahlreiche Zytokine und Wachstumsfaktoren zu synthetisieren und freizusetzen. Interleukin 6 (IL-6), ein bedeutsamer Differenzierungsfaktor für T-Lymphozyten, gehört zu den quantitativ am häufigsten von glatten Gefäßmuskelzellen sezernierten Interleukinen und wird insbesondere nach Stimulation mit IL-1 und anderen Wachstumsfaktoren freigesetzt.
Release of interleukin-6 (IL-6) from human vascular smooth muscle cells
Abstract
Immunological processes mediated by cytokines are assumed to play an important role in atherogenesis. Besides monocytes, endothelial cells and T-cells, also vascular smooth muscle cells (SMC) are able to synthezise and release various cytokines and growth factors. IL-6, an important T-cell differentiation factor, is quantitatively one of the main secretory products of SMC and can be secreted in large amounts in response to IL-1 and other growth factors.
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