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Invasives Karzinom der Vagina

  • Sven AckermannEmail author
  • Christian Dannecker
  • Lars-Christian Horn
  • Celine Alt-Radtke
  • Hans-Georg Schnürch
  • Peer Hantschmann
  • Wolfgang Weikel
  • Linn Wölber
  • Simone Marnitz-Schulze
  • Jana Barinoff
  • Grit Mehlhorn
  • Andreas Günthert
  • Peter Mallmann
Chapter

Zusammenfassung

Vaginalkarzinome gehören zu den seltenen Tumoren (etwa 500 Fälle pro Jahr in Deutschland). Risikofaktoren sind die HPV-Infektion, Immundepression, Nikotinabusus und HPV-assoziierte Vorerkrankungen der Cervix uteri und der Vulva. Als teilweise Primärprävention kann die HPV-Impfung gelten. Eine systematische Früherkennung existiert angesichts der Seltenheit der Erkrankung nicht. Auffällige zytologische Befunde bei fehlender oder unauffälliger Zervix sollten zu einer intensivierten Untersuchung mit Inspektion und Kolposkopie veranlassen. Es handelt sich überwiegend um Plattenepithelkarzinome. Die definitive Diagnostik erfolgt durch histologische Sicherung. Zum Staging werden erst in fortgeschritteneren Stadien bildgebende Verfahren eingesetzt. Im Stadium I kann eine operative Resektion durchgeführt werden, die übrigen Stadien werden einer Radio(chemo)therapie zugeführt. Als Lymphabflussgebiete der Vaginalkarzinome müssen sowohl inguinofemoralen als auch die pelvinen Lymphknoten gelten. Das Sentinel-Verfahren kann zur Beschränkung der Therapieausdehnung eingesetzt werden.

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  • Sven Ackermann
    • 1
    Email author
  • Christian Dannecker
    • 2
  • Lars-Christian Horn
    • 3
  • Celine Alt-Radtke
    • 13
  • Hans-Georg Schnürch
    • 4
  • Peer Hantschmann
    • 5
  • Wolfgang Weikel
    • 6
  • Linn Wölber
    • 7
  • Simone Marnitz-Schulze
    • 8
  • Jana Barinoff
    • 9
  • Grit Mehlhorn
    • 10
  • Andreas Günthert
    • 11
  • Peter Mallmann
    • 12
  1. 1.FrauenklinikKlinikum DarmstadtDarmstadtDeutschland
  2. 2.Klinik und Poliklinik für Frauenheilkunde und GeburtshilfeKlinikum der Universität MünchenMünchenDeutschland
  3. 3.Arbeitsgruppe Mamma-, Gynäko- & Perinatalpathologie Institut für PathologieUniversitätsklinikum LeipzigLeipzigDeutschland
  4. 4.Ehem Lukaskrankenhaus NeussKaarstDeutschland
  5. 5.Klinik für Frauenheilkunde und GeburtshilfeKreiskliniken Altötting-BurghausenAltöttingDeutschland
  6. 6.Klinik und Poliklinik für Geburtshilfe und FrauengesundheitUniversitätsmedizin der Johannes Gutenberg-Universität MainzMainzDeutschland
  7. 7.Klinik und Poliklinik für GynäkologieUniversitätsklinikum Hamburg-EppendorfHamburgDeutschland
  8. 8.Klinik und Poliklinik für StrahlentherapieUniversitätsklinikum KölnKölnDeutschland
  9. 9.Klinik für GynäkologieCharité BerlinBerlinDeutschland
  10. 10.ErlangenDeutschland
  11. 11.FrauenklinikLuzerner KantonsspitalLuzernSchweiz
  12. 12.Klinik und Poliklinik für Frauenheilkunde und GeburtshilfeUniversitätsklinikum KölnKölnDeutschland
  13. 13.Institut für Diagnostische und Interventionelle RadiologieUniversitätsklinikum DüsseldorfDüsseldorfDeutschland

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