Advertisement

Dopplersonographie in der Mammadiagnostik

  • M. Braun
  • M. Schelling
Chapter

Zusammenfassung

Dieses Kapitel beschreibt die farbcodierte Dopplersonographie in der Mammadiagnostik, die ein relativ weites Feld potenzieller Anwendungen bei der Dignitätsbeurteilung und erweiterten Diagnostik von Mammatumoren bietet. Doppersonographische Beurteilungskriterien sind dabei die qualitative und quantitative Bewertung von Gefäßdichte und Gefäßmorphologie sowie die Analyse von Flussprofilen bezüglich der Gefäßwiderstände und Strömungsgeschwindigkeiten. Neben den pathophysiologischen Hintergründen werden die apparativen Voraussetzungen, Messtechniken, diagnostische Kriterien und der Einsatz von Kontrastmittel erläutert. Besondere Bedeutung besitzt die sonographische und dopplersonographische Dignitätsbeurteilung.

Literatur

  1. Adler, D.D., Carson, P.L., Rubin, J.M., Ouinn-Reid, D.: Doppler ultrasound color flow imaging in the study of breast cancer; preliminary findings. Ultrasound Med. Biol., 16, S.553-559, 1990CrossRefGoogle Scholar
  2. Catalano O, Raso MM, D’Aiuto M, Illiano LA, Saturnino PP, Siani A (2009) Additional role of colour Doppler ultrasound imaging in intracystic breast tumours. Radiol Med. 114(2):253)CrossRefGoogle Scholar
  3. Cosgrove, D., Bamber, J., Davey, J., McKinna, J.A. Sinnet, H.D.: Color doppler signals from breast tumors. Radiology, 1761, S.75-80, 1990Google Scholar
  4. Dickler MN, Barry WT, Cirrincione CT, Ellis MJ, Moynahan ME, Innocenti F, Hurria A, Rugo HS, Lake DE, Hahn O, Schneider BP, Tripathy D, Carey LA, Winer EP, Hudis CA (2016) Phase III Trial Evaluating Letrozole As First-Line Endocrine Therapy With or Without Bevacizumab for the Treatment of Postmenopausal Women With Hormone Receptor-Positive Advanced-Stage Breast Cancer: CALGB 40503 (Alliance). J Clin Oncol. 34(22):2602–9CrossRefGoogle Scholar
  5. Du J, Li FH, Fang H, Xia JG, Zhu CX (2008) Microvascular architecture of breast lesions: evaluation with contrast-enhanced ultrasonographic micro flow imaging. J Ultrasound Med.27(6):833–42CrossRefGoogle Scholar
  6. Esen, G., Gurses, B., Yilmaz, M.H., Ilvan, S., Ulus, S., Celik, V., Farahmand, M., Calay, O.O.: Gray scale and power Doppler US in the preoperative evaluation of axillary metastases in breast cancer patients with no palpable lymph nodes. Eur Radiol, 15, S.1215-1223,. 2005CrossRefGoogle Scholar
  7. Folkman, J., Merler, E., Abernathy, C., Williams, G. Isolation of a tumor factor responsible or angiogenesis. J Exp Med,133, S 275–288, 1971CrossRefGoogle Scholar
  8. Folkman, J., Merler, E., Abernathy, C., Williams, G. Isolation of a tumor factor responsible or angiogenesis. J Exp Med,133, S 275–288, 1971CrossRefGoogle Scholar
  9. Germer U, Tetzlaff A, Geipel A, K. Diedrich K, Gembruch U (2002) Strong impact of estrogen environment on Doppler variables used for differentiation between benign and malignant breast lesions. Ultrasound Obstet Gynecol 19: 380–385CrossRefGoogle Scholar
  10. Giuliano AE, Ballman K, McCall L, Beitsch P, Whitworth PW, Blumencranz P, Leitch AM, Saha S, Morrow M, Hunt KK (2010) Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial. Ann Surg. 252:426–32PubMedPubMedCentralGoogle Scholar
  11. Hergan, K., Haid, A., Zimmermann, G., Oser, W.: Präoperative Axillasonographie beim Mammakarzinom: Wertigkeit der Methode im Routinebetrieb. Ultraschall Med. 17, S.14-17, 1996CrossRefGoogle Scholar
  12. Hillen F, Griffioen A (2007) Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev. 26:489–502CrossRefGoogle Scholar
  13. Hoyt K, Umphrey H, Lockhart M, Robbin M, Forero-Torres A (2015) Ultrasound imaging of breast tumor perfusion and neovascular morphology. Ultrasound in Med. & Biol. 41(9): 2292–2302; 20CrossRefGoogle Scholar
  14. Klintman M, Dowsett M (2015) Early Surrogate Markers of Treatment Activity: Where Are We Now? J Natl Cancer Inst Monogr (51):24–8CrossRefGoogle Scholar
  15. Kumar A, Singh S, Pradhan S, Shukla, Ansari M, Singh T, Shyam R, Gupta S (2007) Doppler ultrasound scoring to predict chemotherapeutic response in advanced breast cancer. World Journal of Surgical Oncology.5:99CrossRefGoogle Scholar
  16. Lee, S.K., Lee, T., Lee, K.R., Su, Y.G. Liu, T.J.: Evaluation of breast tumors with color doppler imaging: a comparison with image-directed doppler ultrasound. Journal of clinical ultrasound, 23, S.367-373, 1995CrossRefGoogle Scholar
  17. Lee, W.J., Chu, J.S., Huang, C.S., Chang, M.F., Chang, K.J., Chen, K.M.: Breast cancer vascularity: Color Doppler sonography and histopathology study. Breast Cancer Res. Treat. 37, S.291-298, 1996CrossRefGoogle Scholar
  18. Madjar, H., Prömpeler, H., Wolfahrt, R., Bauknecht, T. Pfleiderer, A.: Farbdopplerflußdaten von Mammatumoren. Ultraschall in Med., 15, S.69-76, 1994CrossRefGoogle Scholar
  19. Madjar, H., Prömpeler, H., Wolfahrt, R., Bauknecht, T., Pfleiderer, A.: Farbdopplerflussdaten von Mammatumoren. Ultraschall Med, 15, S. 69-73, 1994CrossRefGoogle Scholar
  20. Madjar, H., Sauerbrei, W., Prömpeler, H.J., Wolfarth, R., Gufler, H.: Color Doppler and duplex flow analysis for classification of breast lesions. Gynecol Oncol, 64, S. 392-403, 1997CrossRefGoogle Scholar
  21. Obermair, A., Czerwenka, K., Kurz, C., Kaider, A., Sevelda, P.: Tumorale Gefäßdichte bei Mammatumoren und ihr Einfluß auf das rezidivfreie Überleben. Chirurg., 65, S.611-615, 1994PubMedGoogle Scholar
  22. Pinero, A., Reus, M., Illana, J., Duran, I., Martinez-Barba, E., Canteras, M., Parrilla, P.: Palpable breast lesions: utility of Doppler sonography for diagnosis of malignancy. Breast, 12, S. 258-263, 2003CrossRefGoogle Scholar
  23. Santamaria, G., Velasco, M., Farre, X., Vanrell, J.A., Cardesa, A., Fernandez, P.L.: Power Doppler sonography of invasive breast carcinoma: does tumor vascularization contribute to prediction of axillary status? Radiology, 234, S. 374-380, 2005CrossRefGoogle Scholar
  24. Schelling, M., Gnirs, J., Braun, M., Busch, R., Maurer, S., Kuhn, W., Schneider, KTM, Graeff, H.: Optimized differential diagnosis of breast lesions by combined B-mode and color Doppler sonography. Ultrasound Obstet. Gynecol. 10, S.48-53, 1997Google Scholar
  25. Seymour, M.T., Moscovic, E.C., Walsh, G., Trott, P., Smith, I.E.: Ultrasound assessment of residual abnormalities following primary chemotherapy for breast cancer. Br. J. Cancer, 76, S.371-376, 1997CrossRefGoogle Scholar
  26. Singha G, Kumara P, Parshadb R, Seithc A, Thulkarc S, Hostend N (2010) Role of color Doppler indices in predicting disease-free survival of breast cancer patients during neoadjuvant chemotherapy. European Journal of Radiology. 75(2): e158–62CrossRefGoogle Scholar
  27. Toi, M., Taniguchi, T., Yamamoto, Y., Kurisaki, T., Suzuki, H., Tominaga, T.: Clinical significance of the determination of angiogenetic factors. Eur. J. Cancer, 32A, S.2513-2519, 1996CrossRefGoogle Scholar
  28. Vallone, P., D’Angelo, R., Filice, S., Petrosino, T., Rinaldo, M., De Chiara, A., Gallipoli, A.: Color-doppler using contrast medium in evaluating the response to neoadjuvant treatment in patients with locally advanced breast carcinoma. Anticancer Res, 25, S. 595-599, 2005PubMedGoogle Scholar
  29. Weidner, N., Semple, J.P., Welch, W.R., Folkman, J.: Tumor angiogenesis and metastasis–correlation in invasive breast carcinoma. N Engl J Med, 324: S. 1-8, 1991CrossRefGoogle Scholar
  30. Weinstein, S.P., Conant, E.F., Sehgal, C.M., Woo, I.P., Patton, J.A.: Hormonal variations in the vascularity of breast tissue. J Ultrasound Med. 24, S. 67–72, 2005CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland 2018

Authors and Affiliations

  • M. Braun
    • 1
  • M. Schelling
    • 2
  1. 1.Rotkreuzklinikum MünchenFrauenklinikHauptabteilung GynäkologieMünchenDeutschland
  2. 2.praenatalschall.dePraxis für pränatale Diagnostik MünchenMünchenDeutschland

Personalised recommendations