Advertisement

Coagulation diagnostics

  • Dirk Peetz
  • Jürgen Koszielny
  • Michael Spannagl

Abstract

Coagulation analysis systems deployed for POCT feature a great range of different methods and designs. These methods encompass easy-to-use tests for monitoring anticoagulants and assessing plasmatic coagulation alongside more complex, viscoelastic analytical techniques for the simultaneous measurement of plasmatic and cellular hemostasis as well as of platelet function.

References

  1. 1.
    Ak K, Isbir CS, Tetik S, Atalan N, Tekeli A, Aljodi M, Civelek A, Arsan S (2009) Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: a prospective randomized study. J Card Surg 24:404–10CrossRefPubMedGoogle Scholar
  2. 2.
    Avidan MS, Alcock El, Da Fonseca JH et al. (2004) Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth 92: 178–86CrossRefPubMedGoogle Scholar
  3. 3.
    Boldt J, Walz G, Triem J, Suttner S, Kumle B (1998) Point-of-care (POC) measurement of coagulation after cardiac surgery. Intensive Care Med 24: 1187–93CrossRefPubMedGoogle Scholar
  4. 4.
    Calatzis A, Heesen M, Spannagl M (2003) Patientennahe Sofortdiagnostik von Hämostaseveränderungen in der Anästhesie und Intensivmedizin. Anaesthesist 52: 229–37Google Scholar
  5. 5.
    Cammerer U, Dietrich W, Rampf T, Braun SL, Richter JA (2003) The predictive value of modified computerized thromboelastography and platelet function analysis for postoperative blood loss in routine cardiac surgery. Anesth Analg 96: 51–7Google Scholar
  6. 6.
    Christensen TD, Johnsen SP, Hjortdal VE, Hasenkam JM (2007) Self-management of oral anticoagulant therapy: A systematic review and meta-analysis. Int J Cardiol 118: 54–61CrossRefPubMedGoogle Scholar
  7. 7.
    Clarkesmith DE, Pattison HM, Lane DA (2013) Educational and behavioural interventions for anticoagulant therapy in patients with atrial fibrillation. Cochrane Database of Systematic Reviews, Issue 6. Art. No.: CD008600Google Scholar
  8. 8.
    Colucci G, Giabbani E, Barizzi G, Urwyler N, Alberio L (2011) Laboratory-based ROTEM analysis: implementing pneumatic tube transport and real-time graphic transmission. Int J Lab Hematol 33:441–6CrossRefPubMedGoogle Scholar
  9. 9.
    Cuker A, Siegal D, Crowther M, Garcia D (2014) Laboratory measurement of the anticoagulant activity of the non–vitamin K oral anticoagulants. J Am Coll Cardiol 64: 1128–39CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Ebner M, Peter A, Spencer C, Härtig F et al. (2015) Point-of-care testing of coagulation in patients treated with non-vitamin K antagonist oral anticoagulants. Stroke 46 (10): 2741–7CrossRefPubMedGoogle Scholar
  11. 11.
    Ferraris VA, Ferraris SP et al. (2011). Update to The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Blood Conservation Clinical Practice Guidelines. Ann Thorac Surg 91: 944–82Google Scholar
  12. 12.
    Goodnough LT, Hill CC (2012) Use of point-of-care testing for plasma therapy. Transfusion 52 Suppl 1:56S-64S. Erratum in: Transfusion 52:2496CrossRefPubMedGoogle Scholar
  13. 13.
    Harenberg J, Du S, Wehling M, Zolfaghari S et al. (2016) Measurement of dabigatran, rivaroxaban and apixaban in samples of plasma, serum and urine, under real life conditions. An international study. Clin Chem Lab Med. 54: 275–83Google Scholar
  14. 14.
    Heneghan C, Alonso-Coello P, Garcia-Alamino JM, Perera R, Meats E, Glasziou P (2006) Self-monitoring of oral anticoagulation: a systematic review and meta-analysis. Lancet 367: 404–11CrossRefGoogle Scholar
  15. 15.
    Karger R, Donner-Banzhoff N, Müller HH et al. (2007) Diagnostic performance of the platelet function analyzer (PFA-100) for the detection of disorders of primary haemostasis in patients with a bleeding history–a systematic review and meta-analysis. Platelets 18: 249–60CrossRefPubMedGoogle Scholar
  16. 16.
    Koscielny J, Tempelhoff GF, Ziemer S et al. (2004) A practical concept for preoperative management in patients with impaired primary hemostasis. Clinical and Applied Thrombosis/Hemostasis 10: 55–166 and [16a] 195–204CrossRefPubMedGoogle Scholar
  17. 17.
    Koscielny J, Kiesewetter H, Tempelhoff GF (2006) Platelet Function Analyzer (PFA)-100 closure time in the evaluation of platelet disorders and platelet function. Journal of Thrombosis and Haemostasis 4:1426–7CrossRefPubMedGoogle Scholar
  18. 18.
    Levi M, Hunt BJ (2015) A critical appraisal of point-of-care coagulation testing in critically ill patients. J Thromb Haemost 13:1960–7CrossRefPubMedGoogle Scholar
  19. 19.
    Matchar DB, Jacobson A, Dolor R, Edson R, Uyeda L, Phibbs CS et al. (2010) Effect of home testing of international normalized ratio on clinical events. N Engl J Med 363:1608–20. Erratum in: N Engl J Med 364: 93CrossRefPubMedGoogle Scholar
  20. 20.
    Mc Cahon D, Murray ET, Jowett S et al. (2007) Patient self management of oral anticoagulation in routine care in the UK. J Clin Pathol 60: 1263–7Google Scholar
  21. 21.
    Pfanner, G, Koscielny J, Pernerstorfer T et al. (2007) Empfehlungen der Arbeitsgruppe perioperative Gerinnung (AGPG) der Österreichischen Gesellschaft für Anästhesiologie, Reanimation und Intensivmedizin (ÖGARI). Die präoperative Blutungsanamnese. Anästhesist, 56(6):604–11 und [21a] Präoperative Anamnese-basierte Gerinnungsevaluierung. Update June 2013. http://www. oegari.at/web_files/dateiarchiv/editor/anamnese-basierte_gerinnungsabklaerung_vor_op_2013_1.pdf (Status 19 May 2016)
  22. 22.
    Simon DI, Liu CB, Ganz P et al. (2001) A comparative study of light transmission aggregometry and automated bedside platelet function assays in patients undergoing percutaneous coronary intervention and receiving abciximab, eptifibatide, or tirofiban. Catheter Cardiovasc Interv 52:425–32CrossRefPubMedGoogle Scholar
  23. 23.
    Smith JW, Steinhubl SR, Lincoff AM et al. (1999) Rapid platelet-function assay: an automated and quantitative cartridge-based method. Circulation 99:620–5CrossRefPubMedGoogle Scholar
  24. 24.
    Steinhubl SR, Talley JD, Braden GA et al. (2001) Point-of-care measured platelet inhibition correlates with a reduced risk of an adverse cardiac event after percutaneous coronary intervention: results of the GOLD (AU-Assessing Ultegra) multicenter study. Circulation 103:2572–8Google Scholar
  25. 25.
    Weber CF, Görlinger K, Meininger D, Herrmann E, Bingold T, Moritz A, Cohn LH, Zacharowski K (2012) Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology 117:531–47CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Dirk Peetz
    • 1
  • Jürgen Koszielny
    • 2
  • Michael Spannagl
    • 3
  1. 1.HELIOS Klinikum Berlin-BuchInstitut für LaboratoriumsmedizinBerlinGermany
  2. 2.Charité-Universitätsmedizin BerlinInstitut für TransfusionsmedizinBerlinGermany
  3. 3.HeidelbergGermany

Personalised recommendations