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Bio-orthopaedics pp 325–335Cite as

Biological Augmentation in Acute ACL Repair

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Abstract

Anterior cruciate ligament (ACL) injuries are commonly associated with functional impairment. Currently, reconstruction of the ACL with tendon graft is commonly used to restore knee stability. Despite successful outcomes achieved from surgical reconstruction, donor side morbidity, poor proprioception, and incomplete return to high risk sports are potential disadvantages of this procedure. There is great interest in regenerative methods of ACL repair that preserve the proprioceptive function and the architecture of the native ligament insertion. Recent investigations have demonstrated the potential for ACL healing and knee stability restoration after primary suture repair of the ligament, augmented with the use of growth factors and bone marrow derived mesenchymal stem cells. Advances in such therapies are encouraging, given the significant advantages of treatment methods that preserve native ACL anatomy, kinematics, and proprioception.

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Author information

Authors and Affiliations

  1. Orthopaedic Arthroscopic Surgery International Bioresearch Foundation, Gobbi NPO, GA Amadeo 24, 20133, Milan, Italy

    Alberto Gobbi

  2. New York Presbyterian Hospital/Queens, New York, NY, USA

    Graeme P. Whyte MD, MSc, FRCSC

  3. O.A.S.I. Bioresearch Foundation, Milan, Italy

    Graeme P. Whyte MD, MSc, FRCSC

Authors
  1. Alberto Gobbi
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  2. Graeme P. Whyte MD, MSc, FRCSC
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Corresponding author

Correspondence to Alberto Gobbi .

Editor information

Editors and Affiliations

  1. O.A.S.I. Bioresearch Foundation NPO, Milan, Italy

    Alberto Gobbi

  2. Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal

    João Espregueira-Mendes

  3. Musculoskeletal and Joint Research Foundation, San Diego, California, USA

    John G. Lane

  4. Department of Orthopedics, Acibadem University, Istanbul, Turkey

    Mustafa Karahan

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Gobbi, A., Whyte, G.P. (2017). Biological Augmentation in Acute ACL Repair. In: Gobbi, A., Espregueira-Mendes, J., Lane, J., Karahan, M. (eds) Bio-orthopaedics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54181-4_25

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  • DOI: https://doi.org/10.1007/978-3-662-54181-4_25

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-54180-7

  • Online ISBN: 978-3-662-54181-4

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