Intrathekale Medikamentengabe durch implantierbare Pumpen

  • Volker Tronnier
Chapter

Zusammenfassung

Nachdem Mitte der 70er-Jahre zunächst die Opioidrezeptoren und wenig später die endogenen Liganden, die Enkephaline, Endorphine und das Dynorphin entdeckt wurden, erfolgte bereits 1979 die erste klinische peri(epi)durale und intrathekale Anwendung von Opiaten (Behar et al. 1979; Wang et al. 1979). Ende der 80er-Jahre wurde die intrathekale Therapie von Baclofen zur Behandlung der Spastik eingeführt (Müller et al. 1988). Seit den 80er-Jahren sind mehr als 300.000 Pumpen bei unterschiedlichen Indikationen implantiert worden. Im Folgenden soll die chronische intrathekale Therapie mit implantierbaren Pumpen vorgestellt werden. Kurzzeitige Spinalanästhesien oder die perioperative Analgesie mittels externer Pumpen soll nicht Thema dieses Kapitels sein. Die Sicherheit und Effektivität der intrathekalen Therapie konnte in einer Vielzahl von Studien nachgewiesen werden (u. a. Cousins und Mather 1984; Krames 1993; Deer et al. 2002).

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  • Volker Tronnier
    • 1
  1. 1.Klinik für NeurochirurgieUniversitätsklinikum Schleswig-Holstein Campus LübeckLübeckDeutschland

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