• Gudrun RatzingerEmail author
  • Bernhard Zelger
Part of the Springer Reference Medizin book series (SRM)


Histiozytosen kommen durch eine Ansammlung von dendritischen Zellen oder Makrophagen zustande. 5 Gruppen werden unterschieden: die Langerhans-Zell-Gruppe, kutane und mukokutane Non-Langerhans-Zell-Histiozytosen, maligne Histiozytosen, die Rosai-Dorfman Krankheit und die hämophagozytische Lymphohistiozytose. Die seltenen Langerhans-Zell-Histiozytosen umfassen lokalisierte bis generalisierte sowie selbstlimitierende bis lebensbedrohliche Manifestationen bei Kindern und Erwachsenen. Am häufigsten sind Knochen und Haut betroffen. Den häufigeren, zumeist gutartig verlaufenden Non-Langerhans-Zell-Histiozytosen liegt eine nodulär bis diffuse Makrophagen-dominierte Dermatitis zugrunde. Die Xanthogranulom-Familie betrifft vorwiegend Kinder, meistens kommt es zu Spontanremission. Die weiteren Histiozytosen sind sehr selten. Lebensbedrohlich können die malignen Histiozytosen oder die hämophagozytische Lymphohistiozytose verlaufen.


Die Langerhans-Gruppe (L-Gruppe)

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Kutane Nicht-Langerhanszell-Histiozytosen (C-Gruppe)

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Morbus Rosai-Dorfmann (R-Gruppe)

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Maligne Histiozytosen (M-Gruppe)

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Hämophagozytische Lymphohistiozytose (H-Gruppe)

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Universitätsklinik für Dermatologie und VenerologieMedizinische UniversitätInnsbruckÖsterreich

Section editors and affiliations

  • Roland Kaufmann
    • 1
  1. 1.Direktor der Klinik für Dermatologie, Venerologie und AllergologieKlinikum der J.W.Goethe-UniversitätFrankfurt am MainDeutschland

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