Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspectives

  • Stefano Zaffagnini
  • Magali Cucchiarini
  • Laura de Girolamo
  • Peter Angele
  • Helder Pereira
  • Rui L. Reis
  • Henning Madry
  • Carlotta Perucca Orfei
  • Johannes Zellner
  • Giuseppe Filardo


Meniscal tears are common, prevalent intra-articular knee injury and the most frequent cause of orthopedic surgical procedures [1], being a significant risk factor for the development of osteoarthritis (OA) [2]. As widely documented in the previous chapters, tears in the peripheral (vascularized) portion of the meniscus can be repaired using a variety of operative procedures, while those in the central (avascular) area have a poorer healing capacity. Reconstruction of a torn meniscus in this location is challenging, and the long-term effect of allografts on the progression of OA remains uncertain [3].


Tissue Engineering Meniscal Tear Meniscal Repair Meniscal Lesion Meniscal Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Parts of this chapter have been published by Angele et al., JEO1 (2014).


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Copyright information

© ESSKA 2016

Authors and Affiliations

  • Stefano Zaffagnini
    • 1
  • Magali Cucchiarini
    • 2
  • Laura de Girolamo
    • 3
  • Peter Angele
    • 4
    • 5
  • Helder Pereira
    • 6
    • 7
    • 8
    • 9
  • Rui L. Reis
    • 10
    • 8
  • Henning Madry
    • 2
    • 11
  • Carlotta Perucca Orfei
    • 3
  • Johannes Zellner
    • 4
  • Giuseppe Filardo
    • 1
  1. 1.II Clinic – Biomechanics and Innovation Technology LaboratoryRizzoli Orthopaedic InstituteBolognaItaly
  2. 2.Center of Experimental OrthopaedicsSaarland University Medical CenterHomburg/SaarGermany
  3. 3.Orthopaedic Biotechnology LaboratoryIRCCS Galeazzi Orthopaedic InstituteMilanItaly
  4. 4.Department of Trauma SurgeryUniversity Medical Center RegensburgRegensburgGermany
  5. 5.SporthopaedicumRegensburgGermany
  6. 6.Orthopedic DepartmentCentro Hospitalar Póvoa de Varzim - Vila do CondeVila do CondePortugal
  7. 7.3B’s Research Group – Biomaterials, Biodegradables and BiomimeticsUniv. Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineGuimarãesPortugal
  8. 8.ICVS/3B’s – PT Government Associated LaboratoryBragaPortugal
  9. 9.Ripoll y De Prado Sports Clinic FIFA Medical Centre of ExcellenceMurcia-MadridSpain
  10. 10.Tissue Engineering and Regenerative Medicine, 3B’s Research Group – Biomaterials, Biodegradables and BiomimeticsUniversity Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineGuimarãesPortugal
  11. 11.Department of Orthopaedic SurgerySaarland University Medical CenterHomburg/SaarGermany

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