Multifunctional Quantum Dot-Based Nanoscale Modalities for Theranostic Applications

Chapter
First Online:
Part of the Springer Series in Biomaterials Science and Engineering book series (SSBSE, volume 6)

Abstract

Quantum dots (QD) have shown unprecedented fluorescent properties that are capable of revolutionising the field of optical imaging. Due to its unique fluorescent properties, QD have been extensively explored as imaging reagents for the investigation of various biological behaviours in vitro and in vivo. The design and engineering of multifunctional, QD-based modalities have recently attracted enormous interest for simultaneous imaging and therapy. The presence of QD as imaging agent in the theranostic modalities allows for the visualisation of their behaviour in real time and, thus, allows the monitoring of biodistribution, the percentage of drugs in the target site and regional uptake of the drug, as well as clearance from the body in real time, after systematic administration. All this information obtained from QD-based theranostic modalities is believed to be greatly helpful for the better understanding of biological behaviours and further optimization of novel therapeutic modalities, in preclinical and clinical investigations. This chapter attempts to give a brief overview of QD ranging from fundamental knowledge to multifunctional QD-based theranostic modalities for gene therapy, chemotherapy and photodynamic therapy.

Keywords

Multifunctional modality QD Theranostics Cancer therapy and imaging Nanomedicine Optical imaging 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Laboratory of Biophysics and Surface Analysis Division, School of PharmacyUniversity of NottinghamNottinghamUK

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