Advertisement

Markerallergene von Kräuterpollen: diagnostischer Nutzen im klinischen Alltag

  • Gabriele Gadermaier
  • Teresa Stemeseder
  • Wolfgang Hemmer
  • Thomas Hawranek
Chapter

Zusammenfassung

Der Sammelbegriff Kräuter bezeichnet sowohl Pflanzen, die als Küchenkräuter oder Heilpflanzen Verwendung finden, als auch die ökologisch anpassungsfähigen Beikräuter. In Europa werden allergische Reaktionen gegen Kräuter vorwiegend durch Pollen aus Traubenkraut, Beifuß, Spitzwegerich und Glaskraut ausgelöst. Die Sensibilisierungshäufigkeit unterliegt geografischen Schwankungen und kann in bestimmten Regionen mehr als 50 % der Pollenallergiker betreffen. Aufgrund überlappender Blühzeiten, ähnlicher Habitate, Polysensibilisierungen und kreuzreaktiver (Pan-)Allergene ist eine genuine Kräuterpollensensibiliserung mit Extrakten schwierig zu diagnostizieren. Für alle wichtigen Kräuterpollen stehen jedoch Markerallergene für die Komponentendiagnostik zu Verfügung; es sind dies Amb a 1 (Traubenkraut), Art v 1 (Beifuß), Pla l 1 (Spitzwegerich) und Par j 2 (Glaskraut). Die molekulare Allergiediagnostik erlaubt die Identifizierung des primären Auslösers und unterstützt somit die Auswahl des Kräuterextraktes für die spezifische Immuntherapie.

Literatur

  1. Asero R, Wopfner N, Gruber P, Gadermaier G, Ferreira F (2006) Artemisia and Ambrosia hypersensitivity: co-sensitization or co-recognition? Clin Exp Allergy 36:658–665CrossRefPubMedGoogle Scholar
  2. Asero R, Monsalve R, Barber D (2008) Profilin sensitization detected in the office by skin prick test: a study of prevalence and clinical relevance of profilin as a plant food allergen. Clin Exp Allergy 38:1033–1037CrossRefPubMedGoogle Scholar
  3. Asero R, Bellotto E, Ghiani A, Aina R, Villalta D, Citterio S (2014) Concomitant sensitization to ragweed and mugwort pollen: who is who in clinical allergy? Ann Allergy Asthma Immunol 113:307–313CrossRefPubMedGoogle Scholar
  4. Boehme MW, Kompauer I, Weidner U, Piechotowski I, Gabrio T, Behrendt H (2013) Respiratory symptoms and sensitization to airborne pollen of ragweed and mugwort of adults in Southwest Germany. Dtsch Med Wochenschr 138:1651–1658CrossRefPubMedGoogle Scholar
  5. Bouley J, Groeme R, Le Mignon M, Jain K, Chabre H, Bordas-Le Floch V, Couret MN, Bussières L, Lautrette A, Naveau M, Baron-Bodo V, Lombardi V, Mascarell L, Batard T, Nony E, Moingeon P (2015) Identification of the cysteine protease Amb a 11 as a novel major allergen from short ragweed. J Allergy Clin Immunol doi:10.1016/j.jaci.2015.03.001 ([Epub ahead of print], www.ncbi.nlm.nih.gov/pubmed/25865353)
  6. Calabozo B, Diaz-Perales A, Salcedo G, Barber D, Polo F (2003) Cloning and expression of biologically active Plantago lanceolata pollen allergen Pla l 1 in the yeast Pichia pastoris. Biochem J 372:889–896PubMedCentralCrossRefPubMedGoogle Scholar
  7. Canis M, Becker S, Groger M, Kramer MF (2012) IgE reactivity patterns in patients with allergic rhinoconjunctivitis to ragweed and mugwort pollens. Am J Rhinol Allergy 26:31–35CrossRefPubMedGoogle Scholar
  8. Costa MA, Colombo P, Izzo V, Kennedy H, Venturella S, Cocchiara R et al (1994) cDNA cloning, expression and primary structure of Par jI, a major allergen of Parietaria judaica pollen. FEBS Lett 341:182–186CrossRefPubMedGoogle Scholar
  9. Dedic A, Gadermaier G, Vogel L, Ebner C, Vieths S, Ferreira F et al (2009) Immune recognition of novel isoforms and domains of the mugwort pollen major allergen Art v 1. Mol Immunol 46:416–421CrossRefPubMedGoogle Scholar
  10. Egger M, Mutschlechner S, Wopfner N, Gadermaier G, Briza P, Ferreira F (2006) Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view. Allergy 61:461–476CrossRefPubMedGoogle Scholar
  11. Egger M, Hauser M, Mari A, Ferreira F, Gadermaier G (2010) The role of lipid transfer proteins in allergic diseases. Curr Allergy Asthma Rep 10:326–335CrossRefPubMedGoogle Scholar
  12. Gadermaier G, Hauser M, Egger M, Ferrara R, Briza P, Santos KS et al (2011) Sensitization prevalence, antibody cross-reactivity and immunogenic peptide profile of Api g 2, the non-specific lipid transfer protein 1 of celery. PLoS One 6:e24150PubMedCentralCrossRefPubMedGoogle Scholar
  13. Gadermaier G, Eichhorn S, Vejvar E, Weilnbock L, Lang R, Briza P et al (2014a) Plantago lanceolata: An important trigger of summer pollinosis with limited IgE cross-reactivity. J Allergy Clin Immunol 134:472–475. doi:10.1016/j.jaci.2014.02.016CrossRefPubMedGoogle Scholar
  14. Gadermaier G, Hauser M, Ferreira F (2014b) Allergens of weed pollen: An overview on recombinant and natural molecules. Methods 66:55–66CrossRefPubMedGoogle Scholar
  15. Gruber P, Gadermaier G, Bauer R, Weiss R, Wagner S, Leonard R et al (2009) Role of the polypeptide backbone and post-translational modifications in cross-reactivity of Art v 1, the major mugwort pollen allergen. Biol Chem 390:445–451CrossRefPubMedGoogle Scholar
  16. Hafner RP, Salapatek A, Patel D, Larche M, Laidler P (2012) Validation of Peptide Immunotherapy as a New Approach in the Treatment of Rhinoconjunctivitis: The Clinical Benefits of Treatment with Amb a 1 Derived T cell Epitopes. J Allergy and Clin Immunol 129(Suppl):AB368Google Scholar
  17. Heinzerling LM, Burbach GJ, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini S et al (2009) GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. Allergy 64:1498–1506CrossRefPubMedGoogle Scholar
  18. Himly M, Jahn-Schmid B, Dedic A, Kelemen P, Wopfner N, Altmann F et al (2003) Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domain. Faseb J 17:106–108PubMedGoogle Scholar
  19. Hirschwehr R, Heppner C, Spitzauer S, Sperr WR, Valent P, Berger U et al (1998) Identification of common allergenic structures in mugwort and ragweed pollen. J Allergy Clin Immunol 101:196–206CrossRefPubMedGoogle Scholar
  20. Jahn-Schmid B, Fischer GF, Bohle B, Fae I, Gadermaier G, Dedic A et al (2005) Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 *01. J Allergy Clin Immunol 115:399–404CrossRefPubMedGoogle Scholar
  21. Jahn-Schmid B, Hauser M, Wopfner N, Briza P, Berger UE, Asero R et al (2012) Humoral and cellular cross-reactivity between Amb a 1, the major ragweed pollen allergen, and its mugwort homolog Art v 6. J Immunol 188:1559–1567CrossRefPubMedGoogle Scholar
  22. Leonard R, Wopfner N, Pabst M, Stadlmann J, Petersen BO, Duus JO et al (2010) A new allergen from ragweed (Ambrosia artemisiifolia) with homology to Art v 1 from mugwort. J Biol Chem 285:27192–27200PubMedCentralCrossRefPubMedGoogle Scholar
  23. Marmiroli N, Maestri E (2014) Plant peptides in defense and signaling. Peptides 56C:30–44CrossRefGoogle Scholar
  24. Moverare R, Larsson H, Carlsson R, Holmquist I (2011) Mugwort-sensitized individuals from North Europe, South Europe and North America show different IgE reactivity patterns. Int Arch Allergy Immunol 154:164–172CrossRefPubMedGoogle Scholar
  25. Oberhuber C, Ma Y, Wopfner N, Gadermaier G, Dedic A, Niggemann B et al (2008) Prevalence of IgE-binding to Art v 1, Art v 4 and Amb a 1 in mugwort-allergic patients. Int Arch Allergy Immunol 145:94–101CrossRefPubMedGoogle Scholar
  26. Orovitg A, Guardia P, Barber D, de la Torre F, Rodriguez R, Villalba M et al (2011) Enhanced diagnosis of pollen allergy using specific immunoglobulin E determination to detect major allergens and panallergens. J Investig Allergol Clin Immunol 21:253–259PubMedGoogle Scholar
  27. Razzera G, Gadermaier G, de Paula V, Almeida MS, Egger M, Jahn-Schmid B et al (2010) Mapping the interactions between a major pollen allergen and human IgE antibodies. Structure 18:1011–1021CrossRefPubMedGoogle Scholar
  28. Sanchez-Lopez J, Tordesillas L, Pascal M, Munoz-Cano R, Garrido M, Rueda M et al (2014) Role of Art v 3 in pollinosis of patients allergic to Pru p 3. J Allergy Clin Immunol 133:1018–1025 (e3)CrossRefPubMedGoogle Scholar
  29. Smith M, Jager S, Berger U, Sikoparija B, Hallsdottir M, Sauliene I et al (2014) Geographic and temporal variations in pollen exposure across Europe. Allergy 69:913–923. doi:10.1111/all.12419CrossRefPubMedGoogle Scholar
  30. Stemeseder T, Hemmer W, Hawranek T, Gadermaier G (2014) Marker allergens of weed pollen – basic consideration and diagnostic benefits in the clinical routine. Part 16 of the Series Molecular Allergology. Allergo J Int 23:274–280PubMedCentralCrossRefPubMedGoogle Scholar
  31. Stemeseder T, Klinglmayr E, Moser S, Lang R, Himly M, Gschwendtner L et al (2014) Influences of environmental triggers and lifestyle on the development of allergic sensitizations Congress of the European Academy of Allergy and Clinical Immunology,, Kopenhagen, Denmark.Google Scholar
  32. Stumvoll S, Westritschnig K, Lidholm J, Spitzauer S, Colombo P, Duro G et al (2003) Identification of cross-reactive and genuine Parietaria judaica pollen allergens. J Allergy Clin Immunol 111:974–979CrossRefPubMedGoogle Scholar
  33. Tordesillas L, Sirvent S, Diaz-Perales A, Villalba M, Cuesta-Herranz J, Rodriguez R et al (2011) Plant lipid transfer protein allergens: no cross-reactivity between those from foods and olive and Parietaria pollen. Int Arch Allergy Immunol 156:291–296CrossRefPubMedGoogle Scholar
  34. Wallner M, Pichler U, Ferreira F (2013) Recombinant allergens for pollen immunotherapy. Immunotherapy 5:1323–1338CrossRefPubMedGoogle Scholar
  35. Wopfner N, Jahn-Schmid B, Schmidt G, Christ T, Hubinger G, Briza P et al (2009) The alpha and beta subchain of Amb a 1, the major ragweed-pollen allergen show divergent reactivity at the IgE and T-cell level. Mol Immunol 46:2090–2097CrossRefPubMedGoogle Scholar
  36. Ziska L, Knowlton K, Rogers C, Dalan D, Tierney N, Elder MA et al (2011) Recent warming by latitude associated with increased length of ragweed pollen season in central North America. Proc Natl Acad Sci USA 108:4248–4251PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Gabriele Gadermaier
    • 1
  • Teresa Stemeseder
    • 4
  • Wolfgang Hemmer
    • 3
  • Thomas Hawranek
    • 2
  1. 1.Fachbereich Molekulare Biologie, CD Labor für Biosimilar CharakterisierungUniversität SalzburgSalzburgÖsterreich
  2. 2.Universitätsklinik für DermatologieParacelsus Medizinische Universität SalzburgSalzburgÖsterreich
  3. 3.FAZ, Floridsdorfer AllergiezentrumWienÖsterreich
  4. 4.Fachbereich Molekulare BiologieUniversität SalzburgSalzburgÖsterreich

Personalised recommendations