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Evaluation of Cell Line Suitability for Disease Specific Perturbation Experiments

Conference paper
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Part of the Studies in Classification, Data Analysis, and Knowledge Organization book series (STUDIES CLASS)

Abstract

Cell lines are widely used in translational biomedical research to study the genetic basis of diseases. A major approach for experimental disease modeling are genetic perturbation experiments that aim to trigger selected cellular disease states. In this type of experiments it is crucial to ensure that the targeted disease-related genes and pathways are intact in the used cell line. In this work we are developing a framework which integrates genetic sequence information and disease-specific network analysis for evaluating disease-specific cell line suitability.

Keywords

Huntington Disease Betweenness Centrality Perturbation Experiment Disease Network Identical Genetic Background 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Luxembourg Centre for Systems BiomedicineUniversity of LuxembourgEsch-sur-AlzetteLuxembourg

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