Evaluation of Cell Line Suitability for Disease Specific Perturbation Experiments

Conference paper
Part of the Studies in Classification, Data Analysis, and Knowledge Organization book series (STUDIES CLASS)


Cell lines are widely used in translational biomedical research to study the genetic basis of diseases. A major approach for experimental disease modeling are genetic perturbation experiments that aim to trigger selected cellular disease states. In this type of experiments it is crucial to ensure that the targeted disease-related genes and pathways are intact in the used cell line. In this work we are developing a framework which integrates genetic sequence information and disease-specific network analysis for evaluating disease-specific cell line suitability.


Huntington Disease Betweenness Centrality Perturbation Experiment Disease Network Identical Genetic Background 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Luxembourg Centre for Systems BiomedicineUniversity of LuxembourgEsch-sur-AlzetteLuxembourg

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