Linearization of Median Genomes under DCJ

  • Shuai Jiang
  • Max A. Alekseyev
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8701)


Reconstruction of the median genome consisting of linear chromosomes from three given genomes is known to be intractable. There exist efficient methods for solving a relaxed version of this problem, where the median genome is allowed to have circular chromosomes. We propose a method for construction of an approximate solution to the original problem from a solution to the relaxed problem and prove a bound on its approximation accuracy. Our method also provides insights into the combinatorial structure of genome transformations with respect to appearance of circular chromosomes.


DCJ median genome circular chromosome 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Shuai Jiang
    • 1
  • Max A. Alekseyev
    • 1
  1. 1.Computational Biology InstituteThe George Washington UniversityAshburnU.S.A.

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