In vitro Treatment of Marrow with ATCG or Campath-1 for Prophylaxis of GVHD

Results of the AG-KMT München
  • H. J. Kolb
  • H. Rodt
  • B. Netzel
  • G. Hale
  • R. J. Haas
  • Ch. Bender-Götze
  • W. Wilmanns
  • H. Waldmann
  • S. Thierfelder
Chapter
Part of the Experimental Hematology book series (HEMATOLOGY)

Abstract

Graft-versus-host disease (GVHD) is a major obstacle of allogeneic bone marrow transplantation. Presumably mature T-lymphocytes in the marrow graft are responsible for the GVH reaction resulting in GVHD. We have studied removal of T-lymphocytes by treatment of the marrow with absorbed antithymocyte globulin (ATCG) and recently monoclonal antibodies for prevention of GVHD in mice, dogs and man (Rodt et al. 1972, Kolb et al. 1979, Thierfelder et al. 1984). Crossreacting antibodies against hemopoietic stem cells were removed by absorption with liver, kidney, red cells and B-lymphocytes. Campath 1 is a monoclonal antibody produced in a rat hybridoma that reacts against all human lymphocytes and fixes human complement (Hale et al.1983).

Keywords

Graft Failure Total Body Irradiation Allogeneic Bone Marrow Transplantation Antibody Treatment Hemopoietic Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Rodt H. et al. Blut 25: 385, 1972PubMedCrossRefGoogle Scholar
  2. Kolb H.J. et al. Transplant. 27: 242, 1979CrossRefGoogle Scholar
  3. Thierfelder S. et al. Exp. Hematol. 12: 373, 1984Google Scholar
  4. Hale G. et al. Blood 62: 873, 1983PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • H. J. Kolb
    • 1
    • 2
    • 3
  • H. Rodt
    • 1
    • 2
    • 3
  • B. Netzel
    • 1
    • 2
    • 3
  • G. Hale
    • 1
    • 2
    • 3
  • R. J. Haas
    • 1
    • 2
    • 3
  • Ch. Bender-Götze
    • 1
    • 2
    • 3
  • W. Wilmanns
    • 1
    • 2
    • 3
  • H. Waldmann
    • 1
    • 2
    • 3
  • S. Thierfelder
    • 1
    • 2
    • 3
  1. 1.III. Medizinische Klinik, Kinderklinik, KinderpoliklinikUniversität MünchenMünchenFederal Republic of Germany
  2. 2.Gesellschaft für Strahlen- und UmweltforschungInstitut für HämatologieMünchenFederal Republic of Germany
  3. 3.Department of PathologyUniversity of CambridgeGreat Britain

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