Organization of the HLA Class I Region

  • Pierre Pontarotti
  • Giovanna Chimini
  • Catherine Nguyen
  • Joëlle Boretto
  • Bertrand R. Jordan
Chapter

Abstract

HLA class I genes including HLA-A, -B, and -C genes plus 20 to 30 other related sequences are probably all located in the same chromosome region, band p 21.3 of chromosome 6 (1). The genetic map of this region indicates that HLA-A, -B, and -C genes are contained within a segment of 1 centimorgan; the position of the other related genes is not known with certainty, although it appears that most of them are clustered close by and telomeric to the HLA-A gene (2,3).

Keywords

Human Major Histocompatibility Complex Rare Cutter Restriction Rare Cutter Restriction Enzyme Specific Hybridization Probe Frequent Sequence Exchange 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Morton CC, Kirsh IR, Nance WE, Evans GA, Korman AJ, Strominger JL. Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization. Proc Natl Acad Sci USA 1984; 81: 2816–2820.PubMedCrossRefGoogle Scholar
  2. 2.
    Orr HT, Bach FH, Ploegh HL, Strominger JL, Kavathas P, De Mars R. Use of HLA loss mutants to analyse the structure of human major histocompatibility complex. Nature 1982; 296: 454–456.PubMedCrossRefGoogle Scholar
  3. 3.
    Srivastava R, Chorney MJ, Lawrance SK, Pan J, Smith Z, Smith CL, et al. Structure, expression, and molecular mapping of a divergent member of the class I HLA gene family. Proc Natl Acad Sci USA 1987; 84: 4224–4228.PubMedCrossRefGoogle Scholar
  4. 4.
    Lawrance SR, Smith CL, Srivastava R, Cantor CR, Weiss-Google Scholar
  5. man SM. Megabase-scale mapping of the HLA gene complex by pulsed field gel electrophoresis. Science 1987; 235: 1387–1390.CrossRefGoogle Scholar
  6. 5.
    Lindsay S, Bird A. Use of restriction enzymes to detect potention gene sequences in mammalian DNA. Nature 1987; 327: 336–338.PubMedCrossRefGoogle Scholar
  7. 6.
    Bird AP. CpG rich islands and the function of DNA methyl ation. Nature 1986; 321: 200–213.CrossRefGoogle Scholar
  8. 7.
    Strachan T, Sodoyer R, Damotte M, Jordan BR. Completo nucleotide sequence of a functional class I HLA gene, HLA A3. Implication for the evolution of HLA genes. Embo li 1984; 3 (4): 879–885.Google Scholar
  9. 8.
    Srivastava R, Duceman BW, Biro PA, Ashwani KS, Weiss man SH. Molecular organization of the class I genes o’ human major histocompatibility complex. Immunol ReN 1985; 84: 93–121.CrossRefGoogle Scholar
  10. 9.
    Sodoyer R, Damotte M, Delov itch TL, Trucy J, Jordan BR. Strachan T. Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA CW3). Embo J 1984; 3: 879–885.PubMedGoogle Scholar
  11. 10.
    Malissen M, Malissen B, Jordan BR. Exon-Intron organization and complete nucleotide sequence of an HLA gene. Proc Natl Acad Sci USA 1982; 79: 893–897.PubMedCrossRefGoogle Scholar
  12. 11.
    Nguyen C, Pontarotti P, Birnbaum D, Chimini G, Rey JA, Mattei JF, et al. Large scale physical mapping in the q27 region of the human X chromosome: The coagulation factor IX gene and the mcf.2 transforming sequence are separated by at most 270 kilobase pairs and are surrounded by several “HTF islands.” Embo J 1987; 11: 3285–3289.Google Scholar
  13. 12.
    Pease LR, Schulze DH, Pfaffenbach GM, Nathenson SG. Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex. Natl Acad Sci USA 1983; 80: 242–246.CrossRefGoogle Scholar
  14. 13.
    Koller BH, Sidwell B, de Mars R, Orr HT. Isolation of HLA locus specific DNA probes from the 3’ untranslated region. Proc Natl Acad Sci USA 1984; 81: 5175–5178.PubMedCrossRefGoogle Scholar
  15. 14.
    Coppin HL, Denny DW, Weissman SM Jr, McDevitt HO. HLA-B locus polymorphism: Studies with a specific hybridization probe. Proc Natl Acad Sci USA 1985; 82: 8614–8618.PubMedCrossRefGoogle Scholar
  16. 15.
    Strachan T, Dodge AB, Smillie D, Dyer PA, Sodoyer R, Jordan BR, et al. An HLA C specific DNA probe. Immunogenetics 1986; 23: 115–120.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Pierre Pontarotti
    • 1
  • Giovanna Chimini
    • 1
  • Catherine Nguyen
    • 2
  • Joëlle Boretto
    • 1
  • Bertrand R. Jordan
    • 1
  1. 1.Centre d’Immunologie Inserm-CNRS de Marseille-LumingMarseille Cedex 9France
  2. 2.Inserm U242Hopital d Enfants de la TimoneMarseilleFrance

Personalised recommendations