Molecular Structure of Human Class II Antigens

  • John I. Bell
  • John A. Todd
  • Hugh O. Mcdevitt
Chapter

Abstract

There has been remarkable recent progress in characterizing the molecular structure of human class II molecules. This progress has resulted from the rapid accumulation of sequence data from both representatives of each of the major class II loci and from multiple alleles at each locus (1–4). This has permitted an understanding of both the primary structure of these molecules and an appreciation of the polymorphism at each locus. These sequence data can be best understood when analyzed in the context of the three-dimensional structure of the molecule. This can now be achieved by modeling class II sequences to the HLA-A2 crystal structure defined recently by Bjorkman and her colleagues (5,6). This provides not only basic structural information about the antigen binding site, but also allows speculation on the role of individual substitutions in the biological functions of these molecules.

Keywords

Major Histocompatibility Complex Molecule Histocompatibility Antigen Immune Response Gene Antigen Binding Site Human Class 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • John I. Bell
  • John A. Todd
  • Hugh O. Mcdevitt

There are no affiliations available

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