Immunobiology of HLA pp 465-465
B35 and CW4 Are Risk Factors for Development of AIDS
Studies of the HLA system in different groups of patients with the acquired immune deficiency syndrome (AIDS) suggest that genetic factors associated with HLA phenotypes may predispose to the development of the disease. Among the HLA associations claimed to be significant, the most significant is the increased frequency of the HLA-DR5 allele in patients with AIDS and Kaposi’s sarcoma (1,2). In addition, a recent Italian study suggests that HLA-B35 and CW4 represent factors of susceptibility to AIDS (3).
- 3.Scorza Smeraldi R, Fabio G, Lazzarin A, et al. HLA-associated susceptibility to acquired immunodeficiency syndrome in Italian patients with human-immunodeficiency virus infection. Lancet 1986;íi:1187–1189.Google Scholar