B35 and CW4 Are Risk Factors for Development of AIDS

  • M. Jeannet
  • N. A. Carpentier
  • R. Sztajzel
  • P. J. Male
  • B. Hirschel

Abstract

Studies of the HLA system in different groups of patients with the acquired immune deficiency syndrome (AIDS) suggest that genetic factors associated with HLA phenotypes may predispose to the development of the disease. Among the HLA associations claimed to be significant, the most significant is the increased frequency of the HLA-DR5 allele in patients with AIDS and Kaposi’s sarcoma (1,2). In addition, a recent Italian study suggests that HLA-B35 and CW4 represent factors of susceptibility to AIDS (3).

References

  1. 1.
    Pollack MS, Safai B, Myskowski PL, et al. Frequencies of HLA and Gm immunogenetic markers in Kaposi’s sarcoma. Tissue Antigens 1983; 21: 1–8.PubMedCrossRefGoogle Scholar
  2. 2.
    Prince HE, Schroff RW, Ayoub G, et al. HLA studies in acquired immunodeficiency syndrome patients with Kaposi’s sarcoma. J Clin Immunol 1984; 4: 242–245.PubMedCrossRefGoogle Scholar
  3. 3.
    Scorza Smeraldi R, Fabio G, Lazzarin A, et al. HLA-associated susceptibility to acquired immunodeficiency syndrome in Italian patients with human-immunodeficiency virus infection. Lancet 1986;íi:1187–1189.Google Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. Jeannet
    • 1
  • N. A. Carpentier
    • 1
  • R. Sztajzel
    • 1
  • P. J. Male
    • 2
  • B. Hirschel
    • 2
  1. 1.Transplantation Immunology UnitHôpital Cantonal UniversitaireGenevaSwitzerland
  2. 2.Department of MedicineHôpital Cantonal UniversitaireGenevaSwitzerland

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