Immunobiology of HLA pp 450-451 | Cite as
The Role of Lymphotoxin in the Pathogenesis of Celiac Disease
Chapter
Abstract
Celiac disease (CD), a gluten-sensitive enteropathy, has an increased frequency of the serologically defined HLA class II antigens DR3 (90%), DR7 (50%), and DQw2 (95%). The use of Southern blot analysis with DQ and DR a and 13 probes has not further contributed to isolating the HLA-associated disease susceptibility genes. An alternative strategy is to look for variations in the structural patterns of class II-related gene products.
Keywords
Celiac Disease Invariant Chain Queen Elizabeth Hospital Author Affiliation London Hospital Medical College
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
References
- 1.Gray P, Aggerual B, Benton C, Bringman TS, Henzel WJ, Jarrett JA, et al. Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity. Nature 1984; 312: 721.PubMedCrossRefGoogle Scholar
- 2.Spies T, Martin C, Nedopasov S, Fiers W, Pious D, Strominger J. Genes for the two necrosis factors a and 13 are linked to the major histocompatibility complex. PNAS 1986; 83: 8702.CrossRefGoogle Scholar
- 3.Sachs JA, Fernandez N, Kurpisz M, Labeta M, Cabrera T, Razak K, et al. Class II HLA-DR coprecipitate. In: Dupont JA (ed): Immunology of HLA. New York, Springer-Verlag, 1988.Google Scholar
- 4.Meager A, Parti S, Leung H, Woolley J, Peil E, Sidhu S, et al. A two-site sandwich immunoradiometric assay of human lymphotoxin with monoclonal antibodies and its application. J Immunol Methods (in press).Google Scholar
- 5.Pujol-Borrell R, Todd I, Doshin M, Bottazzo GF, Sutton R, Gray P, et al. HLA class II induction in human islet cells by interferon y plus tumour necrosis factor or lymphotoxin. Nature 1987; 326: 304.PubMedCrossRefGoogle Scholar
Copyright information
© Springer Science+Business Media New York 1989