Enzyme pp 1061-1103 | Cite as

Desoxyribonucleasen

  • Günther Siebert
Chapter
Part of the Handbuch der Physiologisch- und Pathologisch-Chemischen Analyse book series (HOPPE-SEYLER, volume Teil B)

Zusammenfassung

Desoxyribonucleasen greifen Internucleotid-Bindungen in Desoxyribo-nucleinsäuren an und sind damit eine spezielle Gruppe von Phosphodiesterasen. Sie werden von den „unspezifischen“ Diesterasen (s. S. 1009ff.) und von Ribonucleasen (s. S. 721ff.) wie folgt abgegrenzt:
  1. 1.

    Im Unterschied zu Phosphodiesterasen werden nur Polynucleotide und Oligonucleotide der Desoxyribose-Reihe angegriffen; Substanzen von Nicht-Nucleotid-Charakter wie z.B. Bis-p-nitrophenylphosphat werden nicht hydrolysiert; es liegt reine „Endonuclease“-Wirkung vor, da terminal stehende Mononucleotide nicht abgespalten werden.

     
  2. 2.

    Im Unterschied zu Ribonucleasen besteht eine absolute, nur in Ausnahmefällen durchbrochene Spezifität für den Nucleinsäure-Baustein Desoxyribose mit allen Konsequenzen hinsichtlich des bei Desoxyribonucleasen rein hydrolytischen Reaktionsmechanismus, da ein Hydroxyl an C-2′ für eine Transfer-Reaktion nicht verfügbar ist; ferner ist die Basen-Spezifität wenig ausgeprägt, da die chemische Natur der Nucleobase (z.B. Pyrimidin oder Purin bzw. Guanin) nicht ausschließlich darüber entscheidet, welche Internucleotid-Bindung gespalten wird.

     
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Copyright information

© Springer-Verlag Berlin Heidelberg 1966

Authors and Affiliations

  • Günther Siebert
    • 1
  1. 1.Physiologisch-Chemisches InstitutJohannes Gutenberg-Universität MainzDeutschland

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