Rat Parvovirus Infection, Liver

  • Robert O. Jacoby
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY, volume 3)


Gross lesions normally occur only in rats infected as infants or fetuses. Mechanical or toxic injury may, however, facilitate virus-induced necrosis in adults (Margolis et al. 1968; Ruffolo et al. 1966). During acute infection, the liver may be soft and pale brown with rounded edges and contain gray-white foci (necrosis) or red foci (laked blood or hemorrhage). These lesions can be accompanied by ascites and icterus (Ruffolo et al. 1966; Coleman et al. 1983; Jacoby et al. 1987). Mild lesions resolve uneventfully, but if necrosis is severe the liver may become firm or nodular due to stromal collapse, fibrosis, and compensatory hepatocytic and biliary hyperplasia. Small, red capsular cysts or elevations resembling those of peliosis hepatis may also develop (Bergs and Scotti 1967).


Rat virus infection Kilham rat virus infection H-1 virus infection 


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© Springer-Verlag Berlin Heidelberg 1997

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  • Robert O. Jacoby

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