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Rat Parvovirus Infection, Liver

  • Robert O. Jacoby
Chapter
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Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY, volume 3)

Abstract

Gross lesions normally occur only in rats infected as infants or fetuses. Mechanical or toxic injury may, however, facilitate virus-induced necrosis in adults (Margolis et al. 1968; Ruffolo et al. 1966). During acute infection, the liver may be soft and pale brown with rounded edges and contain gray-white foci (necrosis) or red foci (laked blood or hemorrhage). These lesions can be accompanied by ascites and icterus (Ruffolo et al. 1966; Coleman et al. 1983; Jacoby et al. 1987). Mild lesions resolve uneventfully, but if necrosis is severe the liver may become firm or nodular due to stromal collapse, fibrosis, and compensatory hepatocytic and biliary hyperplasia. Small, red capsular cysts or elevations resembling those of peliosis hepatis may also develop (Bergs and Scotti 1967).

Synonyms

Rat virus infection Kilham rat virus infection H-1 virus infection 

References

  1. Bergs VV, Scotti TM (1967) Virus-induced peliosis hepatis in rats. Science 158:377–378PubMedCrossRefGoogle Scholar
  2. Burkel WE, Low FN (1966) The fine structure of rat liver sinusoids, space of Disse and associated tissue space. Am J Anat 118:769–783PubMedCrossRefGoogle Scholar
  3. Campbell DA Jr, Staal SP, Menders EK, Bonnard GD, Oldham RK, Salzman LA, Herberman RB (1977) Inhibition of in vitro lymphoproliferative responses by in vivo passaged rat 13762 mammary adenocarcinoma cells. II. Evidence that Kilham rat virus is responsible for the inhibitory effect. Cell Immunol 33:378–391PubMedCrossRefGoogle Scholar
  4. Coleman GL, Jacoby RO, Bhatt PN, Smith AL, Jonas AM (1983) Naturally occurring lethal parvovirus infection of juvenile and young-adult rats. Vet Pathol 20:49–56PubMedGoogle Scholar
  5. Edington GM (1979) Other viral and infectious diseases. In: MacSween RNM, Anthony PP, Scheuer PJ (eds) Pathology of the liver. Churchill Livingstone, New YorkGoogle Scholar
  6. Eldadah AH, Nathanson N, Smith KO, Squire RA, Santos GW, Melby EC (1967) Viral hemorrhagic encephalopathy of rats. Science 156:392–394PubMedCrossRefGoogle Scholar
  7. Gaertner DJ, Jacoby RO, Smith AL, Ardito RB, Paturzo FX (1989) Persistence of rat parvovirus in athymic rats. Arch Virol 105:259–268PubMedCrossRefGoogle Scholar
  8. Gaertner DJ, Jacoby RO, Paturzo FX, Johnson EA, Brandsma JL, Smith AL (1991) Modulation of lethal and persistent rat parvovirus infection by antibody. Arch Virol 118:1–9PubMedCrossRefGoogle Scholar
  9. Gaertner DJ, Jacoby RO, Johnson EA, Paturzo FX, Smith AL, Brandsma JL (1993) Characterization of acute rat parvovirus infection by in situ hybridization. Virus Res 28:1–18PubMedCrossRefGoogle Scholar
  10. Ishak KG (1976) Light microscopic morphology of viral hepatitis. Am J Clin Pathol 65:787–827PubMedGoogle Scholar
  11. Ishak KG. Walker DH, Coetzer JA, Gardner JJ, Gorelkin L (1982) Viral hemorrhagic fevers with hepatic involvement: pathologic aspects with clinical correlations. In: Popper H, Schaffner F (eds) Progress in liver diseases, vol 7. Grune and Stratton, New York, chap 29Google Scholar
  12. Jacoby RO, Bhatt PN, Jonas AM (1979) Viral diseases. In: Baker HJ, Lindsey JR, Weisbroth SH (eds) The laboratory rat, vol 1. Academic, New York, chap 11Google Scholar
  13. Jacoby RO, Bhatt PN, Gaertner DJ, Smith AL, Johnson EA (1987) The pathogenesis of rat virus infection in infant and juvenile rats after oronasal inoculation. Arch Virol 95:251–270PubMedCrossRefGoogle Scholar
  14. Jacoby RO, Gaertner DJ, Bhatt PN, Paturzo FX, Smith AL (1988) Transmission of experimentally induced rat virus infection. Lab Anim Sci 38:11–14PubMedGoogle Scholar
  15. Jacoby RO, Johanson EA, Paturzo FX, Gaertner DJ, Brandsma JL, Smith AL (1991) Persistent rat parvovirus infection in individually housed rats. Arch Virol 117:193–205PubMedCrossRefGoogle Scholar
  16. Jonas AM, Percy DH, Craft J (1970) Tyzzer’s disease in the rat. Its possible relationship with megaloileitis. Arch Pathol 90:516–521PubMedGoogle Scholar
  17. Jubb KVF, Kennedy PC (1970) The liver and biliary system. The nervous system. In: Pathology of domestic animals, 2nd edn, vol 2. Academic, New York, chaps 3, 7Google Scholar
  18. Kilham L (1966) Viruses of laboratory and wild rats. Natl Cancer Inst Monogr 20:117–146PubMedGoogle Scholar
  19. Kilham L, Margolis G (1966) Spontaneous hepatitis and cerebellar hypoplasia in suckling rats due to congenital infections with rat virus. Am J Pathol 49:457–475PubMedGoogle Scholar
  20. Kilham L, Margolis G (1969) Transplacental infection of rats and hamsters induced by oral and parenteral inoculations of H-l and rat viruses (RV). Teratology 2:111–123PubMedCrossRefGoogle Scholar
  21. Kilham L, Olivier LJ (1959) A latent virus of rats isolated in tissue culture. Virology 7:428–437PubMedCrossRefGoogle Scholar
  22. Koff RS, Galambos J (1982) Viral hepatitis. In: Schiff L, Schiff ER (eds) Diseases of the liver, 5th edn, Lippincott, Philadelphia, chap 15Google Scholar
  23. Lipton H, Nathanson N, Hodous J (1972) Enteric transmission of parvoviruses: pathogenesis of rat virus infection in adult rats. Am J Epidemiol 96:443–446PubMedGoogle Scholar
  24. MacSween RNM (1980) Pathology of viral hepatitis and its sequelae. Clin Gastroenterol 9:23–45PubMedGoogle Scholar
  25. Margolis G, Kilham L (1965) Rat virus, an agent with an affinity for the dividing cell. In: Gadjusek DC, Gibbs CJ, Alpers M (eds) Slow, latent and temperate virus infections. US Dept Health Education and Welfare, pp 361–367 (NINDB monographs 2)Google Scholar
  26. Margolis G, Kilham L (1972) Rat virus infection of megakaryocytes: a factor in hemorrhagic encephalopathy? Exp Mol Pathol 16:326–340PubMedCrossRefGoogle Scholar
  27. Margolis G, Kilham L, Ruffolo PR (1968) Rat virus disease, as an experimental model of neonatal hepatitis. Exp Mol Pathol 8:1–20PubMedCrossRefGoogle Scholar
  28. McKisic MD, Paturzo FX, Gaertner DJ, Jacoby RO, Smith AL (1995) Nonlethal rat parvovirus infection suppresses rat T-lymphocyte effector functions. J Immunol 155(8):3979–3986PubMedGoogle Scholar
  29. Poulsen H (1976) Histological features of acute viral hepatitis. Ann Clin Res 8:139–150PubMedGoogle Scholar
  30. Robinson GW, Nathanson N, Hodous J (1971) Sero-epidemiological study of rat virus infection in a closed laboratory colony. Am J Epidemiol 4:91–100Google Scholar
  31. Ruffolo PR, Margolis G, Kilham L (1966) The induction of hepatitis by prior partial hepatectomy in resistant adult rats injected with H-l virus. Light and electron microscopy and virologie studies. Am J Pathol 49:795–824PubMedGoogle Scholar
  32. Siegl G (1976) The parvoviruses. Springer, Vienna New York (Virology monograph, vol 15)CrossRefGoogle Scholar
  33. Smetana HF, Edlow JB, Glunz PR (1965) Neonatal jaundice. A critical review of persistent obstructive jaundice in infancy. Arch Pathol 80:553–574PubMedGoogle Scholar
  34. Smith AL (1983) Response of weanling random-bred mice to inoculation with minute virus of mice. Lab Anim Sci 33:37–39PubMedGoogle Scholar
  35. Steiner JW, Perz ZM, Taichman LB (1966) Cell population dynamics in the liver. A review of quantitative morphological techniques applied to the study of physiological and pathological growth. Exp Mol Pathol 5:146–181PubMedCrossRefGoogle Scholar
  36. Toolan HW (1960) Experimental production of mongoloid hamsters. Science 131:1446–1448PubMedCrossRefGoogle Scholar
  37. Toolan HW (1968) The picodna viruses, H, RV, and AAV. Int Rev Exp Pathol 6:135–180PubMedGoogle Scholar
  38. Yanoff M, Rawson AJ (1964) Peliosis hepatis. An anatomical study with demonstration of two varieties. Arch Pathol 77:159–165PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1997

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  • Robert O. Jacoby

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