The Effects of Negative Stains on Lipids and Proteins Observed in the Electron Microscope
Negative staining techniques have been applied to a wide variety of biological structures, including bacteria, viruses, sub-cellular components, proteins and lipids (cf. Horne 1965). Phospholipids in the form of lecithin as well as mixtures of lecithin and cholesterol have been studied at the molecular level by B a n g h a m and Horne (1964) and Lucy and Glauert (1964). Moreover, modifications of the phospholipid biomolecular leaflet by various chemical agents were also observed.
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- Roth field, L., and R. W. Ho r n e: (To be published.)Google Scholar