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Glutamine and Cancer Cachexia

  • Barrie P. Bode
  • Craig Fischer
  • Steven Abcouwer
  • Masafumi Wasa
  • Wiley W. Souba
Chapter
Part of the Medical Intelligence Unit book series (MIU.LANDES)

Abstract

The observation that cancer cachexia is associated with specific metabolic abnormalities has stimulated several investigators to attempt to correct these deficiencies with the hopes that it would nutritionally benefit the patient with malignant disease. Initial enthusiasm for this approach emerged about 25 years ago when total parenteral nutrition was first introduced into clinical medicine. The provision of exogenous macronutrients to the depleted cancer patient often resulted in weight gain and improved tolerance to anti-neoplastic therapies. More recently, the use of specific nutrients to reverse or combat cancer cachexia has become the focus of study. The amino acid which has received the most attention in this regard has been glutamine and this interest has grown for several reasons. Glutamine is absent from most commercially available TPN formulations. Although glutamine is the most abundant amino acid in the body, a marked glutamine depletion is observed in the host with cancer and a correction of this deficit using glutamine-enriched feedings may translate into functional improvements. Glutamine has been shown to be a regulator of muscle protein synthesis, suggesting that the net muscle catabolism that is observed in cancer patients may be related to altered glutamine metabolism. Furthermore, glutamine is a principal fuel for most rapidly proliferating cancers.

Keywords

Amino Acid Metabolism Cancer Cachexia Glutamine Concentration Glutamine Metabolism Glutaminase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Barrie P. Bode
  • Craig Fischer
  • Steven Abcouwer
  • Masafumi Wasa
  • Wiley W. Souba

There are no affiliations available

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