Export of mRNA Through the Nuclear Pore Complex

  • Wilbert C. Boelens
  • Catherine Dargemont
  • Iain W. Mattaj
Chapter
Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Most of the RNA synthesized in eukaryotic cells must be exported out of the nucleus to fulfill its function. The major classes of exported RNA, divided according to the RNA polymerase responsible for their synthesis and by functional category, are diagrammed in Figure 11.1. During or directly after transcription virtually all primary transcripts undergo several processing events. In the case of the large ribosomal RNAs, transcription, processing and the initial stages of their assembly into ribosomes occurs in a specific sub-compartment of the nucleus, the nucleolus. It has been proposed that the metabolism of other nuclear RNAs may also occur in specific compartments, but this has not been proven (see chapter 10 for a discussion of subnuclear compartments that contain splicing factors). In general, how RNA gets from its transcription or processing site to the nuclear pore complexes (NPC) through which it is exported is not clear. Movement to the NPC may be diffusion-mediated or alternatively RNA may be actively transported to the pores along a nuclear substructure often referred as the nuclear matrix (see ref. 1 for a recent review and references).

Keywords

Nuclear Pore Complex mRNA Export mRNA Transport Nucleocytoplasmic Transport Balbiani Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© R.G. Landes Company and Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Wilbert C. Boelens
  • Catherine Dargemont
  • Iain W. Mattaj

There are no affiliations available

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