Extracellular Matrix in Liver

  • P. R. Sudhakaran
  • N. Anil Kumar
  • Anitha Santhosh
Chapter

Abstract

The extracellular matrix is a complex network of macromolecules that interact with one another as well as with cells in tissues. It comprises both interstitial stroma and the basement membrane that surround the epithelial tissues, nerves, fat cells and muscle. The major components of the extracellular matrix (ECM) in various tissues are collagen, elastins, proteoglycans and glyco-proteins such as fibronectin, laminin, nidogen, entactin, tenascin etc.. Apart from providing physical support to hold cells and tissues together, the ECM provides a highly organised lattice within which the cells can migrate and interact with one another. The interactions of cells with the ECM are critically important in the embryonic development, growth regulation and differentiation. The composition of ECM interacting with cell surface has importantregulatory and structural consequences for cells and an extensive literature now documents these biological roles. The proportion of the ECM and the connective tissue in relation to the parenchymal tissue is very small in liver. Nevertheless, the tasks which the ECM of the liver have to fulfil are complex. It has to combine maximum mechanical stability with minimum hindrance to the free transport of proteins and metabolites between parenchymal cells and the blood stream. In this chapter a brief review on the composition and distribution of extracellular matrix in liver, the interaction of liver cells with the components of the ECM and the biological consequences of these interactions, is presented.

Keywords

Liver Fibrosis Heparan Sulphate Heparan Sulphate Proteoglycan Matrix Substratum Matrix Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • P. R. Sudhakaran
    • 1
  • N. Anil Kumar
    • 1
  • Anitha Santhosh
    • 1
  1. 1.Department of BiochemistryUniversity of KeralaTrivandrumIndia

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