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Mating-Type Cassettes: Structure, Switching and Silencing

  • Benoit Arcangioli
  • Geneviève Thon

Abstract

From a single haploid P (plus) or M (minus) cell, S. pombe is able to produce a population of haploids containing both mating types in nearly equal proportions. This ability is widespread among fungi, the presence of both mating types permitting the formation of diploids and eventually spores. Single-cell lineage approaches have revealed the asymmetry and rules of mating-type switching in S. pombe. Genetic and biochemical analyses have identified the organization of the mating-type loci and a number of genes required for the process of switching. They have yielded insights into the molecular mechanism of the switch and into two processes of epigenetic inheritance. The first process exploits the intrinsic asymmetry of DNA synthesis to restrain a gene conversion event to one of two sister chromatids. The second allows the formation and maintenance of a silent chromatin state. The interplay of both epigenetic events provides a striking example of dynamic chromatin choreography allowing progression into the S. pombe developmental program.

Keywords

Gene Conversion Fission Yeast Schizosaccharomyces Pombe Gene Conversion Event Switching Potential 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Benoit Arcangioli
  • Geneviève Thon

There are no affiliations available

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