Virus-Induced Autoimmune Reactions in the CNS

  • P. J. Talbot
  • D. Arnold
  • J. P. Antel
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 253)


Neurologic diseases are diverse and often not well-understood, despite the tremendous health care problems they pose, such as the estimated 22 million persons worldwide who suffer from dementia, a characteristic loss of mental capacities. Virus infections are an established contributor to development of an array of diseases of the central nervous system (CNS) and are implicated in a further spectrum of disorders in which the etiology is not yet formally established. For example, 60% of acquired immune deficiency syndrome (AIDS) patients suffer neurologic sequelae presumably caused by human immunodeficiency virus (HIV). Viruses can contribute to the development of neurologic disease via an array of direct and indirect mechanisms, as summarized in Table 1 and described in detail in this chapter.


Multiple Sclerosis Multiple Sclerosis Patient Myelin Basic Protein Acquire Immune Deficiency Syndrome Molecular Mimicry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • P. J. Talbot
    • 1
  • D. Arnold
    • 2
  • J. P. Antel
    • 2
  1. 1.Centre de recherche en santé humaineINRS-Institut Armand-Frappier 531LavalCanada
  2. 2.Montreal Neurologic InstituteMcGill UniversityMontrealCanada

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