The Role of T-Cell-Mediated Mechanisms in Virus Infections of the Nervous System

  • R. Dörries
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 253)


For quite a long time, the paucity of immune system elements in the central nervous system (CNS) and its tight enclosure by the blood—brain barrier (BBB) have led to the assumption that this organ is an immunologically privileged site of the body that is rigorously excluded from immune surveillance. However, data accumulated in recent years suggest that this view has to be revised substantially, since the healthy as well as the injured CNS performs an intense and permanent cross-talk with the immune system resulting usually in a well tuned and gradually adapted immune response in the brain (Cserr and Knopf 1992; Fabry et al. 1994).


Microglial Cell Major Histocompatibility Complex Molecule Major Histocompatibility Complex Antigen Peripheral Lymphoid Tissue Major Histocompatibility Complex Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2001

Authors and Affiliations

  • R. Dörries
    • 1
  1. 1.Department of Virology, Institute of Medical Microbiology and HygieneUniversity of HeidelbergMannheimGermany

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