Preclinical Pharmacology of Biguanides

  • N. F. Wiernsperger
Chapter
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 119)

Abstract

Probably few classes of chemicals have generated as many publications as have the biguanides. In the previous review on the preclinical pharmacology of the biguanides in 1971, Beckmann discussed in great detail the pharmacological properties of mainly three biguanide derivatives: phenformin, buformin and metformin. Since that time, important changes have occurred in the form of an almost complete withdrawal of PHEN and BUF from the international markets. On the other hand, a large number of publications have appeared during the last 25 years, most of which have been oriented towards the elucidation of the mode of action of biguanides in diabetes. There are therefore new aspects which must now be considered, for example, prediabetic or non-diabetic insulin resistance, insulin receptor/cell-signaling effects and other properties of potential new applications such as vascular effects.

Keywords

Glucose Uptake Glucose Oxidation Hepatic Glucose Production Metformin Treatment Preclinical Pharmacology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • N. F. Wiernsperger

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