Methods in Proteome and Protein Analysis pp 341-357
Extracting and Searching for Structural Information: A Multiresolution Approach
Nowadays, the scientific community is aware of the importance of the structure of proteins in order to understand the functional events in which they are involved. Indeed, a wide range of diseases are induced by modifications in their structural properties, leading to a loss of protein function (e.g. muscular dystrophy). Thus, protein structure elucidation can provide crucial information about its biochemical function. The two most widely spread methods of protein structure determination, at high resolution, are X-ray diffraction and nuclear magnetic resonance spectroscopy (NMR).
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