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Glutamate-Mediated Synaptic Excitation of Cortical Interneurons

  • J. R. P. Geiger
  • A. Roth
  • B. Taskin
  • P. Jonas
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 141)

Abstract

Principal neurons and interneurons are the two main classes of cells in cortical neuronal networks. Principal neurons (granule cells or pyramidal neurons) have transregional axonal projections and release glutamate onto their postsynaptic target cells. In contrast, interneurons have local, but often extensive, axonal arborizations and use γ-aminobutyric acid (GABA) as a transmitter. Although interneurons represent only approximately 10% of the neuronal population, they control the electrical activity of the entire network (Freund and Buzsáki 1996). Interneurons forming inhibitory synapses on the somata or axon initial segments of their postsynaptic target cells are thought to set the threshold of action potential initiation (Miles et al. 1996) and can synchronize the collective activities of large principal neuron ensembles (Cobb et al. 1995). In contrast, interneurons establishing inhibitory synapses mainly on dendrites could suppress dendritic Na+ or Ca2+ spikes (Buzsáki et al. 1996; Miles et al. 1996) and, thus, regulate plasticity at glutamatergic synapses in the cortex (Davies et al. 1991).

Keywords

Metabotropic Glutamate Receptor Basket Cell Principal Neuron Cortical Interneuron Outer Molecular Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ACPD

trans-1-aminocyclopentane-1,3-dicarboxylic acid

AMPARs

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors

ATPA

2-Amino-3-(3-hydroxy-5-tert-butylisoxazole-4-yl)propanoate

CNS

Central nervous system

D

Diffusion coefficient for glutamate

EPSC

Excitatory postsynaptic current

EPSP

Excitatory postsynaptic potential

GABA

-aminobutyric acid

HICAP

Hilar—commissural-association pathway

HIPP

Hilar—perforant path

KARs

Kainate receptors

LTD

Long-term depression

LTP

Long-term potentiation

mGluRs

Metabotropic glutamate receptors

MCPG

α-methyl-4-carboxyphenyl glycine

MOPP

Molecular layer—perforant path

NMDARs

N-methyl-D-aspartate receptors

OALM

Oriens-alveus—lacunosum moleculare

OML

Outer molecular layer

PPD

Paired-pulse depression

PPF

Paired-pulse facilitation

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© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • J. R. P. Geiger
  • A. Roth
  • B. Taskin
  • P. Jonas

There are no affiliations available

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