Development of Non-Pathogenic Staphylococci as Vaccine Delivery Vehicles

  • Stefan Ståhl
  • Patrik Samuelson
  • Marianne Hansson
  • Christine Andréoni
  • Liliane Goetsch
  • Christine Libon
  • Sissela Liljeqvist
  • Elin Gunneriusson
  • Hans Binz
  • Thien Ngoc Nguyen
  • Mathias Uhlén
Chapter
Part of the Biotechnology Intelligence Unit book series (BIOIU)

Abstract

Among the bacteria being considered as live recombinant vaccine vehicles, the most well studied during the past decade are attenuated Salmonella species1 and mycobacterial bacille Calmette-Guerin (BCG) due to their capacity to colonize mucosal surfaces and invade macrophages in the liver, spleen and lymph nodes of the host.2,3 Surface-display of the foreign antigens to be delivered, has in both these systems proven to be beneficial in eliciting an immune response.4–7 The risk of reversion to a virulent phenotype and the potential side-effects in immunocompromised individuals and infants have, however, raised concern of the use of Salmonella or BCG-based recombinant vaccines in humans.8

Keywords

Human Serum Albumin Surface Display Mucosal Immunization Oral Immunization Recombinant Bacterium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • Stefan Ståhl
  • Patrik Samuelson
  • Marianne Hansson
  • Christine Andréoni
  • Liliane Goetsch
  • Christine Libon
  • Sissela Liljeqvist
  • Elin Gunneriusson
  • Hans Binz
  • Thien Ngoc Nguyen
  • Mathias Uhlén

There are no affiliations available

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