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Virale Infektionen des ZNS

  • Sibylle Schneider-Schaulies
  • Ian C. D. Johnston
  • Jürgen Schneider-Schaulies
Chapter
  • 85 Downloads
Part of the Handbuch der Molekularen Medizin book series (HDBMOLEK, volume 5)

Zusammenfassung

Virale Infektionen des ZNS sind oft lebensbedrohliche Komplikationen systemischer viraler Infektionen. Mit Ausnahme von Tollwut sind sie i.allg. nicht auf einen spezifischen Tropismus des Erregers für das ZNS zurückzuführen. Entero- oder Arboviren induzieren oft erst bei einer Invasion des ZNS klinisch signifikante Erkrankungen. Dies gilt auch für andere Erreger wie Herpes simplex-Virus (HSV). Für die Etablierung viraler ZNS-Infektionen sind nicht nur biologische Eigenschaften des Erregers, sondern auch die Überwindung von Abwehrmechanismen entscheidend, die das ZNS vor Infektionen schützen, insbesondere die Präsenz der Blut-Hirn-Schranke. Aufgrund der Abwesenheit lymphatischer Gewebe im ZNS müssen immunologische Effektormechanismen zunächst in den peripheren lymphatischen Geweben initiiert und generiert werden.

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© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Sibylle Schneider-Schaulies
  • Ian C. D. Johnston
  • Jürgen Schneider-Schaulies

There are no affiliations available

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