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Abstract: Multispectral Imaging Enables Visualization of Spreading Depolarizations in Gyrencephalic Brain

  • Leonardo AyalaEmail author
  • SJ Wirkert
  • MA Herrera
  • Adrián Hernández-Aguilera
  • AS Vermuri
  • E Santos
  • L Maier-Hein
Conference paper
Part of the Informatik aktuell book series (INFORMAT)

Zusammenfassung

Spreading Depolarization (SD) is a phenomenon in the brain related to the abrupt depolarization of neurons in gray matter which results from a break-down of ion gradients across the neuron membrane and propagates like a wave of ischemia. While modulating the hemodynamic response of the SDs is a therapeutic target, the lack of imaging methods that allow for monitoring SDs with high spatiotemporal resolution hinder progress in the field. In this work, we address this bottleneck with a new method for brain imaging based on multispectral imaging (MSI).

Literatur

  1. 1.
    Wirkert SJ, Vemuri AS, Kenngott HG, et al. Physiological parameter estimation from multispectral images unleashed. Proc MICCAI. 2017;1:134–141.Google Scholar

Copyright information

© Springer Fachmedien Wiesbaden GmbH, ein Teil von Springer Nature 2019

Authors and Affiliations

  • Leonardo Ayala
    • 1
    • 2
    • 3
    Email author
  • SJ Wirkert
    • 1
  • MA Herrera
    • 3
  • Adrián Hernández-Aguilera
    • 3
  • AS Vermuri
    • 1
  • E Santos
    • 3
  • L Maier-Hein
    • 1
    • 2
  1. 1.Division of Computer Assisted Medical InterventionsGerman Cancer Research CenterHeidelbergDeutschland
  2. 2.Medical FacultyUniversity of HeidelbergHeidelbergDeutschland
  3. 3.Department of NeurosurgeryHeidelberg University HospitalHeidelbergDeutschland

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