Colo-Proctology pp 163-164 | Cite as
A Prospective Randomised Trial to Compare Mezlocillin and Metronidazole with Cefuroxime and Metronidazole as Prophylaxis in Elective Colorectal Operations
Abstract
Rates of post-operative sepsis following elective colorectal operation range from 10% to 20% [1]. We believe it is safer to use systemic rather than intraluminal antibiotics for prophylaxis, thereby minimising the risks of antibiotic resistance and superinfection from staphylococci and Clostridium difficile [2]. There is considerable debate as to the most appropriate agents for use in these high risk cases. Combination therapy with an imidazole and an agent active against intestinal aerobic bacteria should, in theory, be superior to a single agent. The aim of the present study has been to compare cefuroxime and metronidazole, a combination with activity against most streptococci except enterococci but stable to B-lactamase, with mezlocillin and metronidazole, a combination active against all streptococci but unstable to certain B-lactamases.
Keywords
Clostridium Difficile Prospective Randomise Trial Septic Complication Anastomotic Dehiscence High Risk CaseReferences
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