Three Different Consequences of X-autosome Translocation

  • Susumu Ohno
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 1)


Although they possess the nearly identical DNA value, placental mammals of today display an enormous array of karyotypes, with diploid chromosome numbers ranging from a high of 80 to a low of 17. This indicates that during extensive speciation from a common ancestor, autosomal linkage groups have undergone countless rearrangements. Yet, the original X-chromosome of a common ancestor has apparently been preserved in its entirety by a great majority of placental mammals of today, and in its multiplicated forms by a small number of exceptional species. This conservation of the original X as one unit clearly reveals that the type of X-autosome translocations which split the original X into two separate halves has always been severely deteriorative to speciation, and that these translocations were eliminated as they arose.


Linkage Group Placental Mammal Dosage Compensation Common Shrew Autosomal Gene 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1966

Authors and Affiliations

  • Susumu Ohno
    • 1
  1. 1.Department of BiologyCity of Hope MedicalDuarteUSA

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