Multiple Primary Malignant Neoplasms of Multicentric Origin

  • Charles G. Moertel
Chapter
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 7)

Abstract

Multicentric neoplastic change must be anticipated when a common tissue, presumably endowed with a common susceptibility to malignant disease, is exposed to a common carcinogenic influence. Both of these criteria — a common tissue and exposure to common carcinogenic influence — must be met before true multicentric malignant change will take place. We will demonstrate in this section that multicentric carcinoma of the common squamous epithelium of the oral cavity, pharynx, and larynx occurs quite frequently. However, it has been demonstrated in the previous section and will be amplified in this one that this tendency to multicentricity does not extend to the contiguous columnar epithelium of the trachea and bronchi, although both epithelial surfaces are exposed to the same presumably carcinogenic respiratory irritants. Similarly, multicentric epitheliomas of the skin are exceedingly common in the patient whose occupation requires prolonged exposure of the skin to sun and wind. These lesions, however, are distinctly limited to the exposed surfaces of the skin; the unexposed skin surfaces, although they are of the same type of tissue, are not exposed to the same carcinogenic influence.

Keywords

Carcinoid Tumor Pernicious Anemia Chronic Ulcerative Colitis Bronchogenic Carcinoma Initial Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1966

Authors and Affiliations

  • Charles G. Moertel
    • 1
    • 2
  1. 1.Section of Medicine and Section of Clinical OncologyMayo ClinicUSA
  2. 2.Mayo Graduate School of MedicineUniversity of MinnesotaUSA

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