Perspectives and Prospectives in the Management of Acute Leukemia

  • Edward S. Henderson
Conference paper
Part of the Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 19)

Abstract

The management of and outlook for patients with acute leukemia is strikingly different than it was 10 years ago. The introduction and refinement of empirically based combination chemotherapy in the early 1960’s not only demonstrably improved the response and survival of acute leukemia victims, but equally stimulated basic scientists and clinicians alike to view this malady as an entity which could be cured within the foreseeable future. With this stimulus a remarkable amount of careful, and, often, inspired research has been conducted with the idea of better understanding and controlling this illness. In 1975, the task is not to stimulate interest in the pathogenesis and pathophysiology of leukemia, but to determine whether sufficient information is already available to consistently manage the disease, and, if so, how best to integrate current knowledge.

Keywords

Acute Myelocytic Leukemia Acute Lymphocytic Leukemia Acute Leukemia Roswell Park Memorial Institute Cytosine Arabinoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Edelstein, M., Vietti, T., and Valeriote, F.: Cancer Res. 34: 293, 1974.Google Scholar
  2. 2.
    Omura, G. A. Proc. AACR/ASCO 15: 266, 1975.Google Scholar
  3. 3.
    Weil, M., Jacquillat, C., and Bernard, J. Personal Communication.Google Scholar
  4. 4.
    Yates, J. W., Wallace, H. J., Ellison, R. R., and Holland, J. F. Cancer Chemother. Rep. 57: 485, 1973.Google Scholar
  5. 5.
    Rai, K. R., Holland, J. F., and Glidewell, O. Proc. AACR/.ASCO 15: 265, 1975.Google Scholar
  6. 6.
    Skipper, H. E., Schabel, F. M., Jr., Trader, M. W. Cancer Chemother. Rep. 53: 345, 1969.Google Scholar
  7. 7.
    Fialkow, P. J., Thomas, E. D., Bryant, J. I., and Neiman, P. E. Lancet 1: 251, 1971.CrossRefGoogle Scholar
  8. 8.
    Robinson, R. A., DeVita, V., Levy, H., Barron, S., Hubbard, S., and Levine, A. S., J. Natl. Cancer Inst., in press, 1976.Google Scholar
  9. 9.
    Mathe, G., Amiel, J. L., Schwarzenberg, L., Hayat, M., deVassal, F., Jasmin, C., Rosenfeld, C., Sakoohi, M., and Choay, J. Rev. Eur. Etud., Clin. Biol. 15: 671, 1970.Google Scholar
  10. 10.
    Mathe, G., Amiel, J. L., and Schwarzenberg, L. Rev. Eur. Etud. Clin. Biol. 16: 216, 1971.PubMedGoogle Scholar
  11. 11.
    Gutterman, J. V., Rodriguez, V., Maglavit, G., Burgess, M. A., Gehan, E., Hersh, E. M., McCredie, K. B., Reed, R., Smith, T., Bodey, G. P., Sr., and Freireich, E. J. Lancet 2: 1405, 1974.CrossRefGoogle Scholar
  12. 12.
    Powles, R. L. These Proceedings.Google Scholar
  13. 13.
    Bekesi, J. G., Holland, J. F., Yates, J. W., Henderson, E., and Fleminger, R. Proc. AACR/ASCO 16: 121, 1975.Google Scholar
  14. 14.
    Vogler, W. R., and Chan, Y. K. Lancet 2: 128, 1974.CrossRefGoogle Scholar
  15. 15.
    Weiss, D. W., Stupp, Y., Many, N., and Izak, G. Transplant. Proc. 7: 545, 1975.Google Scholar
  16. 16.
    Lampkin, B. C., McWilliams, N. B., and Mauer, A. M. Seminars in Hematol. 9: 211, 1972.Google Scholar
  17. 17.
    Klein, H. O., and Lennartz, K. J. Seminars in Hematology 11: 203, 1974.Google Scholar
  18. 18.
    Hall, T. C. NCI. Monograph 34: 145, 1971.Google Scholar
  19. 19.
    Halberg, F., Hans, E., Cardoso, S. S., Scheving, L. E., Kuhl, J. F. W., Shiotsuka, R., Rosene, G., Pauly, J. E., Runge, W., Spalding, J. F., Lee, J. K., and Good, R. A. Experientia 29: 909, 1973.CrossRefGoogle Scholar
  20. 20.
    Till, J. E., Mak, T. W., Price, G. B., Senn J. S and McCulloch E A. These Proceedings.Google Scholar
  21. 21.
    Preisler, H. D. These Proceedings.Google Scholar
  22. 22.
    Iscove, N. N. and Sieber, F. (1975), Experimental Hematology, 3, 32.PubMedGoogle Scholar
  23. 23.
    Paul, G. These Proceedings.Google Scholar
  24. 24.
    Forget, B. G., Glass, J., and Housman, D. These Proceedings.Google Scholar
  25. 25.
    Greaves, M. F. These Proceedings.Google Scholar
  26. 26.
    Bloch, A. Biochem. Biol. Res. Com. 58: 652, 1974.CrossRefGoogle Scholar
  27. 27.
    Bloch, A., Hromchak, R., and Henderson, E. S. Proc. AACR/ASCO 15: ’.. 91, 1975.Google Scholar
  28. 28.
    Henderson, E. S., in Hematology, 2nd edition, Williams, W. J., Beutler, E., Erslev, A. J., and Rundles, R. W., eds., McGraw-Hill, New York, 1976, in press.Google Scholar

Copyright information

© J. F. Lehmanns Verlag München 1976

Authors and Affiliations

  • Edward S. Henderson

There are no affiliations available

Personalised recommendations