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Therapy of Atherosclerosis: When?

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Adalat

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Abstract

A pharmacological company looks for the practical application of its discoveries by seeking the introduction onto the market of drugs of value which may be helpful to mankind and undeniably to the well-being of the company itself. A few years ago, our department became involved with a new multinational program of research with the purpose of developing new therapies for atherosclerosis. The relevance of this disease is underscored by two clear facts:

  1. 1.

    Atherosclerosis accounts for a cumulative coronary incidence of about 50%.

  2. 2.

    Atherosclerosis is responsible for 25%–30% of all deaths (Breslow et al. 1989).

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References

  • Asdente M, Pavesi L, Oreste PL, Colombo A, Kuhn W, Tremoli E (1990) Evaluation of atherosclerotic lesions using NMR microimaging. Atherosclerosis 80:243–253

    Article  PubMed  CAS  Google Scholar 

  • Barath P, Fishbein MC, Cao J, Berenson J, Heifant RH, Forrester JS (1990) Detection and localization of tumor necrosis factor in human atheroma. Am J Cardiol 65:297–302

    Article  PubMed  CAS  Google Scholar 

  • Baxter JD, Perloff D, Hsueh W, Biglieri EG (1987) The endocrinology of hypertension. In: Felig P, Baxter JD, Broadus AE, Frohman LA (eds) Endocrinology and metabolism, 2nd edn. McGraw-Hill, New York, pp 694–788

    Google Scholar 

  • Beaumont JL, Doucet F, Vivier P, Antonucci M (1988) Immunoglobulin-bound lipoproteins (IgLp) as markers of familial hypercholesterolemia, xanthomatosis and atherosclerosis. Atherosclerosis 74:191–201

    Article  PubMed  CAS  Google Scholar 

  • Block LH, Emmons LR, Vogt E, Sachinidis A, Vetter W (1989) Ca++-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells. Proc Natl Acad Sci USA 86:2388–2392

    Article  PubMed  CAS  Google Scholar 

  • Breslow JL, Deeb S, Lalouel JM, Le Boeuf R, Schaefer EJ, Tyroler A, Wilson P, Young S (1989) Genetic susceptibility to atherosclerosis. Workshop II. Circulation 80(3):724–728

    Article  PubMed  CAS  Google Scholar 

  • Brindley DN, Rolland Y (1989) Possible connections between stress, diabetes, obesity, hypertension and altered lipoprotein metabolism that may result in atherosclerosis. Clin Sci 77:453–461

    PubMed  CAS  Google Scholar 

  • Brown GB, Lin JT, Schaefer SM, Kaplan CA, Dodge HT (1989) Niacin or lovastatin, combined with colestipol, regress coronary atherosclerosis and prevent clinical events in men with elevated apolipoprotein B. Circulation 80:11–266

    Google Scholar 

  • Carew TE, Schwenke DC, Steinberg D (1987) Antiatherogenic effect of Probucol unrelated to its hypocholesterolemic effect. Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci USA 84:7725–7729

    Article  PubMed  CAS  Google Scholar 

  • D’Anastasio C, Impallomeni M, McPherson GAD, Clements WG, Howells GL, Brooks PA, Batchelor JR (1988) Antibodies against monocytes and endothelial cells in the sera of patients with atherosclerotic peripheral arterial disease. Atherosclerosis 74:99–105

    Article  PubMed  Google Scholar 

  • Etingin OR, Hajjar DP (1990) Calcium channel blockers enhance cholesterol ester hydrolysis and decrease total cholesterol accumulation in human aortic tissue. Circ Res 66:185–190

    Article  PubMed  CAS  Google Scholar 

  • Foegh ML, Khirabadi BS, Chambers E, Ramwell PW (1989) Peptide inhibition of accelerated transplant atherosclerosis. Transplant Proc 21(4):3674–3676

    PubMed  CAS  Google Scholar 

  • Frossard PM, Vinogradov S (1989) Using DNA markers to predict genetic susceptibility to atherosclerosis. In: Lusis AJ, Sparkes SR (eds) Genetic factors in atherosclerosis: approaches and model systems. Monogr Hum Genet 12:110–124

    Google Scholar 

  • Gimbrone MA, Obin MS, Brock AF, Luis EA, Hass PE, Hebert CA, Leung DW, Lowe DG, Kohr WJ, Darbonne WC, Bechtol KB, Baker JB (1989) Endothelial interleukin-8: a novel inhibitor of leukocyte-endothelial interactions. Science 246:1601–1603

    Article  PubMed  CAS  Google Scholar 

  • Gordon D, Schwartz SM, Benditt EP, Wilcox JN (1989) Growth factors and cell proliferation in human atherosclerosis. Transplant Proc 21(4):3692–3694

    PubMed  CAS  Google Scholar 

  • Gutstein WH (1990) The central nervous system and atherogenesis: role of the arterial smooth muscle cell. Atherosclerosis 82:145–155

    Article  PubMed  CAS  Google Scholar 

  • Handa K, Kono S, Saku K, Sasaki J, Kawano T, Sasaki Y, Hiroki T, Arakawa K (1989) Plasma fibrinogen as an independent indicator of severity of coronary atherosclerosis. Atherosclerosis 77:209–213

    Article  PubMed  CAS  Google Scholar 

  • Hansson GK, Jonasson L, Seifert PS, Stemme S (1989) Immune mechanisms in atherosclerosis. Arteriosclerosis 9:567–578

    Article  PubMed  CAS  Google Scholar 

  • Hotz W (1983) Nicotinic acid and derivatives: a short survey 20:195–217

    CAS  Google Scholar 

  • Jialal I, Vega GL, Grundy SM (1990) Physiological levels of ascorbate inhibit the oxidative modification of low density lipoprotein. Atherosclerosis 82:185–191

    Article  PubMed  CAS  Google Scholar 

  • Kaplan KL, Bini A (1989) Thrombosis and atherogenesis. CRC Crit Rev Oncol Hematol 9(4):305–318

    Article  CAS  Google Scholar 

  • Lichtlen P, Hugenholtz PG, Rafflenbeul W, Hecker H, Jost S, Deckers JW (1990) Retardation of angiographic progression or coronary artery disease by Nifedipine. Lancet Vol 335:1109–1113

    Article  PubMed  CAS  Google Scholar 

  • Loaldi A, Polese A, Montorsi P, De Cesare N, Fabbiocchi F, Ravagnani P, Guazzi MD (1989) Comparison of nifedipine, propanolol and isosorbide dinitrate on angiographic progression and regression of coronary arterial narrowings in angina pectoris. Am J Cardiol 64:433–439

    Article  PubMed  CAS  Google Scholar 

  • Makheja AN, Bloon S, Muesing R, Simon T, Bailey JM (1989) Anti-inflammatory drugs in experimental atherosclerosis. 7. Spontaneous atherosclerosis in WHHL rabbits and inhibition by cortisone acetate. Atherosclerosis 76:155–161

    Article  PubMed  CAS  Google Scholar 

  • Mantovani A, Dej ana E (1989) Cytokines as communication signals between leukocytes and endothelial cells. Immunol Today 10(11):370–375

    Article  PubMed  CAS  Google Scholar 

  • McGill HC Jr (1990) Questions about the natural history of atherosclerosis. In: Glagov S, Newman WP, Schaf fer SA (eds) Pathobiology of the human atherosclerotic plaque. Springer, New York, pp 1–11

    Chapter  Google Scholar 

  • Mohiaddin RH, Longmore DB (1989) MRI studies of atherosclerotic vascular disease: structural evaluation and physiological measurements. Br Med Bull 45(4):968–990

    PubMed  CAS  Google Scholar 

  • Morel DW, Chisolm GM (1989) Antioxidant treatment of diabetic rats inhibits lipoprotein oxidation and cytotoxicity. J Lipid Res 30:1827–1834

    PubMed  CAS  Google Scholar 

  • Newmann WP III, Freedman DS, Voors AW et al. (1986) Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis: The Bogaloosa Heart Study. New Engl J Med 314:138–144

    Article  Google Scholar 

  • O’Leary DH, Bryan FA, Goodison MW, Rifkin MD, Gramiak R et al. (1987) Measurement variability of carotid atherosclerosis: real time (B-mode) ultrasonography and angiography. Stroke 18:1011–1017

    Article  PubMed  Google Scholar 

  • Ornish D, Brown SE, Scherwitz LW, Billings JH, Armstrong WT, Ports TA, McLanahan SM, Kirkeeide RL, Brand RJ, Gould KL (1990) Can lifestyle changes reverse coronary heart disease? The lifestyle heart trial. Lancet Vol 336,129–133

    Article  PubMed  CAS  Google Scholar 

  • Pauletto P, Scannapieco G, Borrione A, Zanellato A, Tonello M, Pessina A, Dal Palü C, Sartore S (1990) A Nifedipine-sensitive smooth muscle cell population is present in the atherosclerotic rabbit aorta. (In press)

    Google Scholar 

  • Ross R (1986) The pathogenesis of atherosclerosis — an update. N Engl J Med 314:488–500

    Article  PubMed  CAS  Google Scholar 

  • Ross R, Wight TN, Strandness E (1984) Human atherosclerosis. I. Cell constitution and characteristics of advanced lesions of the superficial femoral artery. Am J Pathol 114:79–86

    PubMed  CAS  Google Scholar 

  • Ross R, Masuda J, Raines EW, Gown AM, Katsuda S, Sasahara M, Maiden LT, Masuko H, Sato H (1990) Localization of PDGF-B protein in macrophages in all phases of atherogenesis. Science 248:1009–1011

    Article  PubMed  CAS  Google Scholar 

  • Schmitz G, Robenek H, Beuk M, Krauss R, Shurek A, Niemann R (1988) Ca++ antagonists and AC AT inhibitors promote cholesterol efflux from macrophages by different mechanisms. Arteriosclerosis 8:46–56

    Article  PubMed  CAS  Google Scholar 

  • Schwenke DC, Carew TE (1989) Initiation of atherosclerotic lesions in cholesterol-fed rabbits. 1. Focal increases in arterial LDL concentration precede development of fatty streak lesions. Arteriosclerosis 9:895–907

    Article  PubMed  CAS  Google Scholar 

  • Simionescu N, Vasile E, Lupu F, Popescu G, Simionescu M (1986) Prelesional events in atherogenesis: accumulation of extracellular cholesterol rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit. Am J Pathol 123:109–125

    PubMed  CAS  Google Scholar 

  • Smith EB, Slater RS, Hunter JA (1973) Quantitative studies in fibrinogen and low-density lipoprotein in human aortic intima. Atherosclerosis 18:479–487

    Article  PubMed  CAS  Google Scholar 

  • Steinberg D (1989a) New targets for anti-atherosclerotic therapy. In: DALM Meeting Highlights — News from the Xth international symposium on drugs affecting lipid metabolism, November 8–11,1989. pag 3. Published by SPN a division of SLACK Inc.

    Google Scholar 

  • Steinberg D (1989b) The cholesterol controversy is over. Why did it take so long? Circulation 80(4):1070–1078

    Article  PubMed  CAS  Google Scholar 

  • Superko HR (1989) Drug therapy and the prevention of atherosclerosis in humans. Am J Cardiol 64:31G–38G

    Article  PubMed  CAS  Google Scholar 

  • Virchow R (1856) Phlogose und Thrombose im Gefäßsystem. Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Meidinger, Frankfurt

    Google Scholar 

  • Wiklund O, Biörnheden T, Olofson S, Bondjers G (1987) Influx and cellular degradation of low density lipoproteins in rabbit aorta determined in an in vitro perfusion system. Arteriosclerosis 7:565–571

    Article  PubMed  CAS  Google Scholar 

  • Williams R (1979) In: Hurst JW (ed): The heart Update IV. McGraw-Hill, New York, pp 89–118

    Google Scholar 

  • Zawadzki Z, Milne RW, Marcel YL (1989) An immunochemical marker of low density lipoprotein oxidation. J Lipid Res 30:885–891

    PubMed  CAS  Google Scholar 

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Authors
  1. A. Faggiotto
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Editors and Affiliations

  1. Abtl. Innere Medizin/Kardiologie, Medizinische Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Germany

    P. R. Lichtlen

  2. Cardiologia Policlinico, Roma, Italy

    A. Reale

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© 1991 Springer-Verlag Berlin Heidelberg

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Faggiotto, A. (1991). Therapy of Atherosclerosis: When?. In: Lichtlen, P.R., Reale, A. (eds) Adalat. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85498-9_20

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  • DOI: https://doi.org/10.1007/978-3-642-85498-9_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85500-9

  • Online ISBN: 978-3-642-85498-9

  • eBook Packages: Springer Book Archive

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