Evidence for muscle fiber hyperplasia in the septum of patients with hypertrophic obstructive cardiomyopathy (HOCM). Quantitative examination of endomyocardial biopsies (EMCB) and myectomy specimens
Conference paper
Abstract
In hypertrophic cardiomyopathy, muscle mass is increased for no apparent reason (6). A familial occurrence in 20% of the cases indicates a genetic disposition. The most important feature of HOCM is a thickening of the septum disproportionate to the hypertrophied free left ventricular wall, whereas the cavity remains normal or is narrowed (14, 18). The catenoid-shaped septum bulges into the outflow tract of the left ventricle and results in its systolic obstruction (8). This obstruction is mainly located in the subaortic region, rarely in the middle or apical parts of the left ventricle (9). The disorganization of muscle fibers is the second hallmark of HOCM. Fiber disarray can be observed in various heart diseases as well as in normal hearts (1, 2, 17, 20), but when its distribution is diffuse (4) and quantitatively substantial (11, 12) it is quite specific to hypertrophic cardiomyopathy.
Keywords
Hypertrophic Cardiomyopathy Volume Density Endomyocardial Biopsy Normal Shape Hypertrophic Obstructive Cardiomyopathy
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