Intracellular Regulation of Ion Channels pp 173-180 | Cite as
Voltage-Dependent Modal Gating in Cardiac and Neuronal L-type Calcium Channels
Conference paper
Abstract
The typical gating kinetics of single L-type calcium channels are characterized by openings of short duration (~ 1 msec mean open time) grouped in bursts which are separated by long periods of inactivity (Hess et al., 1984; Cavalie et al.,1986). Spontaneous occasional appearance of a distinct gating pattern characterized by long openings and high open probability (mode 2) has been reported (Hess et al., 1984), but the frequency of entering this mode is so rare that the importance of the phenomenon, and even its existence, have been doubted.
Keywords
Voltage Dependence Cerebellar Granule Cell Test Potential Single Channel Current Equivalent Charge
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References
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© Springer-Verlag Berlin Heidelberg 1992