Hemopoietic System pp 51-54 | Cite as
Megakaryocytic Leukemia, Mouse
Chapter
Abstract
As with granulocytic and erythrocytic leukemias, the most noticeable lesion in megakaryocytic leukemia is splenic enlargement, often accompanied by marked hepatomegaly. The spleen, which can weigh over 2 g, is brownish-red without blood lakes, consolidated blood clots, or tumor nodules. The color of the liver is similar to that of the spleen, and the degree of hepatic enlargement can be severe in protracted cases. The disease is not associated with grossly discernable hemorrhage or other evidence of clotting disorders.
Synonyms
Megakaryoblastic leukemia megakaryocytic myelosisPreview
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References
- Bennett JM, Catovsky M, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1985) Criteria for the diagnosis of acute leukemia of megakaryocytc lineage (M7). A report of the French-American-British Cooperative Group. Ann Intern Med 103: 460–462PubMedGoogle Scholar
- Dennis LH, Brodsky I (1965) Thrombocytopenia induced by the Friend leukemia virus. JNCI 35: 993–999PubMedGoogle Scholar
- Fredrickson TN, Langdon WY, Hoffman PM, Hartley JW, Morse HC III (1984) Histologic and cell surface antigen studies of hematopoietic tumors induced by Cas-Br-M murine leukemia virus. JNCI 72: 447–454PubMedGoogle Scholar
- Frith CH, Pattengale PK, Ward JM (1985) A color atlas of hematopoietic pathology of mice. Toxicology Pathology Associates, Little RockGoogle Scholar
- Hardy WD (1981) Hematopoietic tumors of cats. J Am Anim Hosp Assoc 17:921–940Google Scholar
- Li Y, Golemis E, Hartley JW, Hopkins N (1987) Disease specificity of nondefective Friend and Moloney murine leukemia viruses is controlled by a small number of nucleotides. J Virol 61: 693–700PubMedGoogle Scholar
- LoBue J, Gordon AS, Weitz-Hamburger A, Ferdinand P, Camiscoli JF, Fredrickson TN, Hardy WD Jr (1974) Erythroid differentiation in murine erythroleukemia. In: Clarkson B and Baserga R (eds) Control of proliferation of animal cells. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp 863–885Google Scholar
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