Trypanosoma Brucei Infection, Mouse

  • Jiro J. Kaneko
  • Victor O. Anosa
Chapter
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

The bone marrow of infected mice is pale at 2 weeks post inoculation (Anosa 1975,1980), and marrow nucleated cell counts decrease more markedly in splenectomized CFLP mice than in intact mice (Anosa 1980). Decreases in marrow nucleated cells counts are minimal in anemic deer mice (Anosa and Kaneko 1983 a). However, marrow RBC counts decrease in both the CRLP mice and in deer mice (Anosa and Kaneko 1983 a).

Synonyms

Trypanosomiasis 
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amole BO, Clarkson AB Jr, Shear HL (1982) Pathogenesis of anemia in T. brucei–infected mice. Infect Immun 36: 1060–1068PubMedGoogle Scholar
  2. Anosa VO (1975) The effect of splenectomy on the anemia and parasitemia of trypanosomiasis. MVM Thesis University of GlasgowGoogle Scholar
  3. Anosa VO (1980) Studies on the parasitaemia, plasma volumes, leucocyte and bone marrow cell counts and the moribund state in T. brucei infection in splenectomized and intact mice. Zentralbl Veterinarmed [B] 27: 169–180CrossRefGoogle Scholar
  4. Anosa VO (1983) Diseases produced by T. vivax in ruminants, horses and rodents. Zentralbl Veterinarmed [B] 30:717–741CrossRefGoogle Scholar
  5. Anosa VO, Kaneko JJ (1983 a) Pathogenesis of T.brucei infection in deer mice (P. maniculatus). Hematologic, erythrocyte biochemical and iron metabolic aspects. Am J Vet Res 44: 639–644PubMedGoogle Scholar
  6. Anosa VO, Kaneko JJ (1983 b) Pathogenesis of T. brucei infection in deer mice (P. maniculatus). Light and electron microscopic studies on erythrocyte pathologic changes and phagocytosis. Am J Vet Res 44: 645–651PubMedGoogle Scholar
  7. Anosa VO, Kaneko JJ (1983 c) Pathogenesis of T.brucei infection in deer mice (P. maniculatus). V. Macrophage ultrastructure and function. Vet Pathol 20: 617–631PubMedCrossRefGoogle Scholar
  8. Anosa VO, Kaneko JJ (1984 a) Pathogenesis of T. brucei infection in deer mice (P. maniculatus). Ultrastructural pathology of the spleen, liver, heart, and kidney. Vet Pathol 21:229–237PubMedGoogle Scholar
  9. Anosa VO, Kaneko JJ (1984b) Pathogenesis of T. brucei infection in deer mice (P. maniculatus). Light and electron microscopic study of testicular lesions. Vet Pathol 21: 238–246PubMedGoogle Scholar
  10. Anosa VO, Jennings FW, Urquhart GM (1977) The effect of splenectomy on anemia in T. brucei infection of mice. J Comp Pathol 87: 569–579PubMedCrossRefGoogle Scholar
  11. Clayton CE (1978) T. brucei influence of host strain and parasite antigenic type of infections in mice. Exp Parasitol 44: 202–208PubMedCrossRefGoogle Scholar
  12. Fierer J, Askonas BA (1982) T. brucei infection stimulates receptor-mediated phagocytosis by murine peritoneal macrophages. Infect Immun 37: 1282–1284PubMedGoogle Scholar
  13. Huan CN, Webb L, Lambert PH, Miescher PA (1975) Pathogenesis of the anemia in African trypanosomiasis. Characterization and purification of a hemolytic factor. Schweiz Med Wochenschr 105: 1582–1583PubMedGoogle Scholar
  14. Ikede BO, Losos GJ (1972) Pathological changes in cattle infected with T. brucei. Vet Pathol 9: 272–277PubMedCrossRefGoogle Scholar
  15. Ikede BO, Fatimah I, Sharifuddin W, Bongso TA (1983) Clinical and pathological features of a natural T. evansi infection in ponies in West Malaysia. Trop Vet 1 : 151–157Google Scholar
  16. Jennings FW, Murray PK, Murray M, Urquhart GM (1974) Anemia in trypanosomiasis: studies in rats and mice infected with T. brucei. Res Vet Sci 16: 70–76PubMedGoogle Scholar
  17. Losos GJ, Ikede BO (1972) Review of the pathology of diseases in domestic and laboratory animals caused by T. congolense, T. vivax, T. brucei, T. rhodesiense and T. gambiense (abstr). Vet Pathol 9: 1–71CrossRefGoogle Scholar
  18. Moulton JE (1980) Experimental T. brucei infection in deer mice: splenic changes. Vet Pathol 17: 218–225PubMedGoogle Scholar
  19. Moulton JE, Stevens DR (1978) Animal model of human disease: trypanosomiasis, sleeping sickness, in deer mice. Am J Pathol 91: 693–696PubMedGoogle Scholar
  20. Poltera AA (1980) Immunological and chemotherapeutic studies in experimental trypanosomiasis with special reference to the heart and brain. Trans R Soc Trop Med Hyg 74: 706–715PubMedCrossRefGoogle Scholar
  21. Poltera AA, Hochmann A, Lambert PH (1980a) A model for cardiopathy induced by T. brucei brucei in mice. A histologic and amunopathologic study. Am J Pathol 99: 325–352PubMedGoogle Scholar
  22. Poltera AA, Hochmann A, Rudin W, Lambert PH (1980 b) T.brucei brucei: a model for cerebral trypanosomiasis in mice — an immunological, histological and electronmicroscopic study. Clin Exp Immunol 40: 496–507PubMedGoogle Scholar
  23. Stevens DR, Moulton JE (1978) Ultrastructural and immunological aspects of the phagocytosis of T. brucei by mouse peritoneal macrophages. Infect Immun 19: 972–982PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Jiro J. Kaneko
  • Victor O. Anosa

There are no affiliations available

Personalised recommendations