Translation Regulation of Frog Virus 3

  • A. M. Aubertin
  • L. Tondre
  • T. N. Tham
Conference paper


Frog virus 3 (FV 3), the amphibian virus the most extensively analyzed belongs to the family Iridoviridae. The study of the multiplication cycle of this virus, isolated by Granoff et al (1966), has revealed several original features such as i) the replication occurs in the nucleus and the cytoplasm of the host cell, ii) the RNA polymerase II is required for immediate early transcription, iii) a structural protein is necessary as transacting factor (for review, Willis et al, 1985) iv) the virus or structural proteins are highly toxic for cells or animals (Kirn, 1970; Aubertin et al, 1973; 1976; Drillien et al, 1977). As expected for a virus with a large genome, its expression is regulated at several levels and in this paper, attention will be focused on the control of translation and the mechanisms will be discussed.


Mouse Mammary Tumor Virus Early Protein Macromolecular Synthesis Frog Virus Late Message 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. M. Aubertin
    • 1
  • L. Tondre
    • 1
  • T. N. Tham
    • 1
  1. 1.Laboratoire de VirologieUnité INSERM U 74StrasbourgFrance

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