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Biology of Leishmania and Leishmaniasis

  • Conference paper
Dermatology in Five Continents

Abstract

After an introduction by Mr. Furtado (Brazil), Mr. Peters (Great Britain) pointed out that four main species of leishmania, L. tropica, braziliensis, mexicana and donovani and their subspecies, are responsible for different clinical manifestations of the disease in geographically limited areas. The histological and electron-microscopic morphology of the parasite in culture and in phagocytes, reported by Mr. Klingmüller (FR Germany) do not permit the differentiation of species and subspecies. For this, the biochemical and immunological characterization is necessary. The best practicable biochemical method to distinguish parasite species and subspecies seems to be the isolation of the parasite strains in culture and their characterization by isoenzyme patterns. To this, culture of parasites should be sent to one of the several WHO international reference centres. The immunological characterization may be performed with monoclonal antibodies, using a radioimmune binding assay. The data mainly support the established main classification of New World Leishmania in species of the complex braziliensis, mexicana and donovani and their respective subspecies.

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References

  1. Stanford JL (1983) In: Ratledge C, Stanford JL (eds) The biology of the mycobacteria, vol 2. Academic Press, London, p 85.

    Google Scholar 

  2. Copras SD (1982) CRC-Crit. Rev Microbiol 9:139.

    Google Scholar 

  3. Bos JD (1986) Immunology Today 7:235.

    Article  Google Scholar 

  4. Adam S, Asch et al. (1986) J Exp Med 163:221.

    Article  Google Scholar 

  5. Samsonetti P, Langrange PH (1981) Rev Infect Dis 3:422.

    Article  Google Scholar 

  6. Rook GAW (1983) In: Ratledge C, Stanford JL (eds) The biology of the mycobacteria. Academic Press, London, p 279.

    Google Scholar 

  7. Godal T (1984) Lepr Rev 55:407.

    PubMed  CAS  Google Scholar 

  8. Bloom B, Mehra V (1984) Immunol Rev 80:5.

    Article  PubMed  CAS  Google Scholar 

  9. Sechal MJ (1985) In the editorial. Int J Lepr 618.

    Google Scholar 

  10. Edwards D, Kirkpatrick CH (1986) Am Rev Respir 134:1062.

    CAS  Google Scholar 

  11. Kaufmann SHE (1986) Microbial Path 1:107.

    Article  CAS  Google Scholar 

  12. Ridley DS (1983) In: Ratledge C, Stanford JL (eds) The biology of mycobacteria. Academic Press, London, p 129.

    Google Scholar 

  13. Spector et al. (1982) J Pathol 136:41.

    Article  PubMed  CAS  Google Scholar 

  14. Collins et al. (1985) Clin Exp Immunol 62:458.

    Google Scholar 

  15. Steward-Tull DES (1983) In: Ratledge C, Stanford JL (eds) The biology of the mycobacteria. Academic Press, London, p 3.

    Google Scholar 

  16. Rozemond R et al. (1985) Clin Exp Immunol 62:482.

    Google Scholar 

  17. Jano et al. (1984) Acta Lepr II, No. 2–4, p 341.

    Google Scholar 

  18. Das et al. (1982) Ann Immunol (Inst Pasteur) 133D:41.

    CAS  Google Scholar 

  19. Das et al. (1986) J Inv Dermatol 87:134.

    Article  Google Scholar 

  20. Holoschitz J et al. (1986) Lancet II:305.

    Article  Google Scholar 

  21. Whitehouse MW (1986) Lancet II:688.

    Article  Google Scholar 

  22. Mitchell DN, Rees RJW (1983) In: Ratledge C, Stanford JL (eds) The biology of the mycobacteria. Academic Press, London, p 525.

    Google Scholar 

  23. Das et al. (1985) Prot Biol Fluid 33:369.

    Google Scholar 

  24. Sandor Husz et al. (1981) Diagn Hist 4:149.

    Google Scholar 

  25. Biozzi G, Mouton D, Stiffel C, Bouthillier Y (1984) A major role of the macrophage in quantitative genetic regulation of immunoresponsiveness and antiinfectious immunity. Adv Immunology 36:189.

    Article  CAS  Google Scholar 

  26. Buchmüller-Rouillier Y, Mauel J (1986) Correlation between enhanced oxidative metabolism and leishmanicidal activity in activated macrophages from healer and non-healer mouse strains. J Immunology 136:3884.

    Google Scholar 

  27. Convit J, Avila JL, Goihman M, Pinardi ME (1972) A test for the determination of competency in clearing bacilli in leprosy patients. Bull World Hlth Org 46:821.

    CAS  Google Scholar 

  28. Goihman-Yahr M, Convit J, Rodríguez-Ochoa G, Aranzazu N, Villalba-Pimentel L, Ocanto A, Gómez MH (1978) Significance of neutrophil activation in reactional leproma-tous leprosy. Effects of Thalidomide in-vitro and in-vivo. Activation in adjuvant disease. Int Arch Allergy Appl Immunol 57:317.

    Article  PubMed  CAS  Google Scholar 

  29. Goihman-Yahr M, Essenfeld-Yahr E, Albornoz MC, Yarzábal L, Gómez MH, San Martín B, Ocanto A, Gil F, Convit J (1980) Defect of in-vitro digestive ability of polymorphonuclear leukocytes in paracoccidioidomycosis. Infect Immun 28:557.

    PubMed  CAS  Google Scholar 

  30. Goihman-Yahr M, Cabello de Brito I. Albornoz MC, de Gómez MH, Pereira J, de Román A, San Martín B, Molina T (1985) Especificidad del defecto digestivo de paracoccidioidomi-cosis. A propósito de 1a enfermedad de Jorge Lobo (Specificity of digestive defect in paracoccidioidomycosis. In relation to Jorge Lobo’s disease). Acta Cient Venez (Suppl 1) 36:75 (abstract).

    Google Scholar 

  31. Goihman-Yahr M, Rothenberg A, Bretaña A, Rosquete R, Avila-Millán E, Viloria N, San Martín B, de Román A, de Gómez MH, Pereira J, Molina T (1985) Digestión leucocitaria de suspensiones autoclavadas y sonicadas de P. brasiliensis (Leukocyte digestion of sonicated and autoclaved suspensions of P. brasiliensis). Acta Cient Venez (Suppl 1) 36:75 (abstract).

    Google Scholar 

  32. Goihman-Yahr M, Rothenberg A, Rosquete R, Avila-Millán E, Albornoz MC, Gómez MH, San Martín B, Ocanto A, Pereira J, Molina T (1985) A novel method for estimating killing ability and digestion of Paracoccidioides brasiliensis by phagocytic cells in-vitro. Sabouraudia 23:245.

    Article  PubMed  CAS  Google Scholar 

  33. Goihman-Yahr M, Rothenberg A, Avila-Millán E, Rosquete R, Albornoz MC, Kanski A, Pereira J, de Gómez MH, de Román A, San Martín B (1985) Las células fagocitarias. Su funcionamiento en las efermedades granulomatosas producidas por agentes vivos. El modelo de la paracoccidioidomicosis (Phagocytic cells. Their function in granulomatous diseases produced by live organisms. Paracoccidioidomycosis as a model. Ciencia y Tecnol Venez 2:193.

    Google Scholar 

  34. Granger DL, Perfect JR, Durack DT (1986) Macrophage-mediated fungistasis: requirement for a macromolecular components in serum. J Immunology 137:693.

    CAS  Google Scholar 

  35. Handman E, Schnur LF, Spithill TW, Mitchell GF (1986) Passive transfer of leishmania lipopolysaccharide confers parasite survival in macrophages. J Immunology 137:3608.

    CAS  Google Scholar 

  36. Hartmann DP, Mala Georgian M, Kagan E (1984) Enhanced alveolar macrophage Ia. antigen expression after asbestos inhalation. J Immunology 132:2693.

    CAS  Google Scholar 

  37. Hoover DL, Nacy CA (1984) Macrophage activation to kill Leishmania tropica: defective intracellular killing of amastigotes by macrophages elicited with sterile inflammatory agents. J Immunology 132:1487.

    CAS  Google Scholar 

  38. Murphy JW, Mosley RL (1985) Regulation of cell mediated immunity in cryptococcosis. III. Characterization of second order T suppressor cells. J Immunology 134:577.

    CAS  Google Scholar 

  39. Oster CN, Nacy CA (1984) Macrophage activation to kill Leishmania tropica: kinetics of macrophage response to lymphokines that induce antimicrobial activities against amastigotes. J Immunology 132:1494.

    CAS  Google Scholar 

  40. Petersen E, Neva FA, Barral A, Correa-Coronas R, Bogaert-Díaz H, Martínez D, Ward FE (1984) Monocyte suppression of antigen specific lymphocyte responses in diffuse cutaneous leishmaniasis patients from the Dominican Republic. J Immunology 132:2603.

    CAS  Google Scholar 

  41. Scott P, Sher A (1986) A spectrum in the susceptibility of leishmanial strains to intracellular killing by murine macrophages. J Immunology 136:1461.

    CAS  Google Scholar 

  42. Tapia FJ, Goihman-Yahr M, Rothenberg A, Viloria N, Rosquete R, Avila-Millán E, Carrasquero M, Albornoz MC, Pereira J, Gómez MH, San Martín B, de Román A, Bretaña A, Molina T (1986) Subpoblaciones linfocitarias en exudados broncoalveolares y sangre periférica de pacientes con enfermedades granulomatosas (Leukocyte sub-sets in bronchoal-veolar fluid and peripheral blood in patients with granulomatous diseases. Acta Cient Venez (Suppl 1) 37:71 (abstract).

    Google Scholar 

  43. Convit J (1974) Leprosy and Leishmaniasis similar clinical immunological pathological models. Ethiop Med J 12:187.

    PubMed  CAS  Google Scholar 

  44. Convit J, Pinardi ME (1974) Cutaneous Leishmaniasis: the clinical and immunopathological spectrum in South America. Ciba Foundation Symposium.

    Google Scholar 

  45. Convit J, Pinardi ME, Rondón AJ (1972) Diffuse cutaneous Leishmaniasis; disease due to immunological defect of the host trans of the Royal Soc. of Trop. Med. and Hyg., vol 66, no 4, pp 603–610.

    Article  CAS  Google Scholar 

  46. Castes M, Agnelli A, Verde O, Rondón AJ (1983) Characterization of the cellular immune response in American Cutaneous Leishmaniasis. Clin Imm Imm 27:176–186.

    Article  CAS  Google Scholar 

  47. Castes M, Agnelli A, Rondón AJ (1984) Mechanisms associated with immunoregulation in human American Cutaneous Leishmaniasis. Clin Exp Immunol 57:279–286.

    PubMed  CAS  Google Scholar 

  48. Bretaña A, Avila JL, Lizardo G, Convit J, Rondón AJ (1983) Leishmania species: comparative ultrastructure of experimental nodules and diffuse human cutaneous lesions in American leishmaniasis. Exp Parasi 55:377–385.

    Article  Google Scholar 

  49. Modlin RL, Tapia F, Bloom B, Gallinato ME, Castes M, Rondón AJ, Rea Th, Convit J (1985) In situ characterization of the cellular immune response in American cutaneous leishmaniasis. Clin Exp Immunol 60:241–248.

    PubMed  CAS  Google Scholar 

  50. Convit J, Rondón A, Ulrich M, Bloom B, Castellanos PL, Pinardi ME, Garcia L (1987) Immunotherapy versus chemotherapy in localised cutaneous leishmaniasis. Lancet I.

    Google Scholar 

  51. Lindenberg A (1909) L’ulcère de Bauru ou le bouton d’Orient au Brésil. Bull Soc Path Exot 2:252–254.

    Google Scholar 

  52. Shaw J (1985) Taxônomia do gênero Leishmania. Conceito tradicionalista X conceito mo-derno. An Brasil Dermatol 60:67–72.

    Google Scholar 

  53. Medina R, Quintana A (1972) Caso de leishmaniasis cutanea en el que se evidenciaram parasitas leishmanicos en la medula ossea. Dermat Venezol 11:304–309.

    Google Scholar 

  54. Joliffe DS, Evans DA, Brycesson ADM (1986) Cutaneous leishmaniasis. Br J Dermatol 114:745.

    Article  Google Scholar 

  55. André R, Brumpt L, Dreyfus B, Passelecq A, Jacob S (1957) Leishmaniose cutanée, leishmaniose ganglionaire et kala-azar transfusionel. Bull Mém Soc Méd Hôp Paris 73:854–860.

    PubMed  Google Scholar 

  56. Bray RS (1972) Leishmaniasis in the Old World. Br Med Bull 28:39–43.

    PubMed  CAS  Google Scholar 

  57. Brahmachari UN (1923) Dermal leishmanoid. J Trop Med Hyg 26:182–183.

    Google Scholar 

  58. Rozenblatt J (1979) Interstitial keratitis caused by American (mucocutaneous) leishmaniasis. J Am Ophthalmol 87:175–179.

    Google Scholar 

  59. Alchorne MMA, Mendonça JS, Amato Neto V, Alchorne A, França LCM, Guiduli Neto J (1986) Leishmaniose tegumentar americana com manifestações sistêmicas. Resumos de Trabalhos, XXXIII Congresso Brasileiro de Dermatologia, Brasília 21 a 25 de setembro, pp4-7.

    Google Scholar 

  60. Hidalgo-Hidalgo H, Solano-Aguillar E, Soto-Pacheco R (1978) Leishmaniasis ganglionar. Libro de Resumenes, XI Congresso Centroamericano de Dermatologia, 24-29 de noviembre, San José, Costa Rica.

    Google Scholar 

  61. Berger TG, Meltzer MS, Oster CN (1985) Lymph node involvement in leishmaniasis. J Am Acad Dermatol 6:993–996.

    Article  Google Scholar 

  62. Dupond JL, Chobault JC, Barale T, Billerey C, Mallet H, Pretot L, Des Floris RL (1984) Leishmaniose laingée chez un jurassien cause insolite de granulomatose épithélioide et gigan-to-cellulaire. Nouvelle Pres Med 13:149–151.

    CAS  Google Scholar 

  63. Farge D, Frances C, Vouldoukis I, Wechsler B, Boisnic S, Monjour L, Godeau P (1987) Chronic destructive ulcerative lesion of the midface and nasal cavity due to leishmaniasis contracted in Djibouti. Clin Exp Dermatol 12:211–213.

    Article  PubMed  CAS  Google Scholar 

  64. Kubba R, El-Hassan AM, Al-Gindan Y, Omer AHS, Kutty MK, Path FRC, Saeed MBM (1987) Dissemination in cutaneous leishmaniasis. I Subcutaneous nodules. Int J Dermatol 26:300–304.

    Article  PubMed  CAS  Google Scholar 

  65. Berlin C, Brenner S (1982) Leishmanid. Is Jr Med Sci 18:285–286.

    CAS  Google Scholar 

  66. Akhound-Zadeh H (1976) Phagédénisme leishmanien. Étude immunologique et expérimentale. Ann Derm Syph 103:23–30.

    CAS  Google Scholar 

  67. Zuckerman A, Sagher F (1963) Experimental cutaneous leishmaniasis. The development of multiple lesions (leishmanid) following the prophylactic inoculation of living Leishmania tropica into a single site. J Invest Dermatol 40:193–198.

    PubMed  CAS  Google Scholar 

  68. Brycesson ADM (1970) Diffuse cutaneous leishmaniasis in Ethiopia, III. IV. IV. Pathogenesis of diffuse cutaneous leishmaniasis. Trans Roy Soc Trop Med Hyg 64:387–393.

    Google Scholar 

  69. Orbaneja JG, Ledo A (1954) Boton de Oriente tipo nodular. Actas dermo-sif 46:815.

    Google Scholar 

  70. Bedi TR, Pandhi RK, Pal D, Buthani LK (1976) Diffuse cutaneous leishmaniasis in India. Castellania 4:203–204.

    Google Scholar 

  71. Steward CD, Pilcher JF (1945) American leishmaniasis. Report of an autochthonous case. Arch Dermatol Syph 51:124–128.

    Article  Google Scholar 

  72. Nelson DA, Gustafson TL, Spielvogel RL (1985) Clinical aspects of cutaneous leishmaniasis acquired in Texas. J Am Acad Dermatol 12:985–992.

    Article  PubMed  CAS  Google Scholar 

  73. Simpson MH, Mullins JF, Stone OJ (1968) Disseminated cutaneous leishmaniasis. An autochthonous case in Texas and Mexican State of Leon. Arch Dermatol 97:301–303.

    Article  PubMed  CAS  Google Scholar 

  74. Corrales-Padilla H, Lainez H (1968) Leishmaniasis cutanea disseminada (Revision del tema e informe del primer caso en Honduras). Med Cut 3:119–123.

    Google Scholar 

  75. Marquez F (1966) Leishmaniasis cutanea disseminada anergica. Presentacion del primer caso observado en Mexico. Med Cut 1:287–292.

    Google Scholar 

  76. Silva DB (1982) Leishmaniose anérgica hansenóide. Med Cut ILA 10:143–150.

    Google Scholar 

  77. Menezes JA, Reis VLL, Thonon S (1978) Perfuração do septo nasal em leishmaniose „cutis difusa“. An Brasil Dermatol 53:199–209.

    Google Scholar 

  78. Convit J, Pinardi ME, Rondon AJ (1972) Diffuse cutaneous leishmaniasis. A disease due to an immunological defect of the host. Trans Roy Soc Trop Med Hyg 66:603–610.

    Article  PubMed  CAS  Google Scholar 

  79. Convit J, Pinardi ME (1974) Cutaneous leishmaniasis. The clinical and immunopathological spectrum in South America. In: Trypanosomiasis and leishmaniasis with special reference to Chagas’ disease, Ciba Foundation Symposium 20, Excepta Medica, Amsterdam, pp 159-166.

    Google Scholar 

  80. Kerdel-Vegas F (1966) Leishmaniasis difusa experimental. Dermatol Rev Mex 10:307–312.

    Google Scholar 

  81. Lainson R, Shaw JJ (1972) Leishmaniasis of the New World: taxonomic problems. Br Med Bull 28:44–48.

    PubMed  CAS  Google Scholar 

  82. Marsden PD, Noronha RR (1975) Mucocutaneous leishmaniasis. A review of clinical aspects. Rev Soc Bras Med Trop 9:309–326.

    Article  Google Scholar 

  83. Silveira FT, Lainson R, Shaw JJ, Ribeiro RSM (1984) Leishmaniose cutânea na Amazonia. Registro do primeiro caso humano de infecção mista determinado por duas espécies distintas de leishmanias: Leishmania braziliensis e Leishmania mexicana amazonensis. Rev Inst Med trop São Paulo 26:272–275.

    Article  PubMed  CAS  Google Scholar 

  84. Costa JML, Tada MS, Lago EL, França F, Vale KC, Osaki NK, Vexenat ACR, Magalhães AV, Marsden PD (1986) Surto epidêmico de leishmaniose tegumentar americana na região de Corte de Pedra (BA). XXII Congresso da Sociedade Brasileira de Medicina Tropical, 2-7 de março.

    Google Scholar 

  85. Cuba CAC, Barreto AC, Marsden PD (1984) Leishmania mexicana: aspectos taxonómicos y rareza de la infección humana en Três Braços, Bahia, Brasil. Rev Soc Bras Med Trop 17:115–122.

    Article  Google Scholar 

  86. Bezert B (1980) La leishmaniose tegumentaire en Guyane Française. (Actualité épidémiolo-gique, clinique, et biologique). Thesis, Universite de Bordeaux II, L’Impression Offset.

    Google Scholar 

  87. Destombes P (1960) Application du concept de «systématization polaire» aux leishmanioses cutanées. Bull Soc Path Exot 53:299–301.

    PubMed  CAS  Google Scholar 

  88. Padilha-Gonçalves A, Guimarães NA (1970) Leishmaniosis. I. Reunión Conjunta de la Canadian Dermatological Association y la Academia Mexicana de Dermatologia y la III Reunión México-Centroamericana de Dermatologia, México D.F, 7-14 de marzo.

    Google Scholar 

  89. Padilha-Gonçalves A (1976) O conceito da polaridade na leishmaniose. XXXIII Congresso Brasileiro de Dermatologia, Livro de Resumos, Brasília, 21–25 de setembro.

    Google Scholar 

  90. Moriearty PL, Bittencourt AL, Pereira C, Teixeira R, Barreto E, Guimarães NA (1978) Borderline cutaneous leishmaniasis. Clinical, immunological and histological differences from mucocutaneous leishmaniasis. Rev Inst Med Trop São Paulo 20:15–21.

    PubMed  CAS  Google Scholar 

  91. Padilha-Gonçalves A (1984) Natural history and classification of American tegumentary leishmaniasis — V World Congress of Tropical Dermatology, Mexico DF, March 16–20.

    Google Scholar 

  92. Ramos e Silva J (1949) Leishmanides. Considerações sobre a forma generalizada da leishmaniose tegumentar americana. Brasil Méd 63:23–26.

    PubMed  Google Scholar 

  93. Ramos e Silva J (1959) Sobre o conceito de leishmanide. Hospital, Rio de Janeiro 55:833–892.

    Google Scholar 

  94. Bowdre JH, Campbell JL, Walker DH, Tart DE (1981) American cutaneous leishmaniasis. Culture of a Leishmania species from peripheral blood leukocytes. Am J Clin Pathol 75:435–438.

    PubMed  CAS  Google Scholar 

  95. Ramos RT, Grimaldi G Jr, Oliveira Neto MP (1982) Isolation of Leishmania from peripheral blood cells in cutaneous and mucocutaneous leishmaniasis in Brazil. Resumos da IX Reunião Anual de Pesquisa Basica em Doença de Chagas, Caxambu, MG, Brasil, resumo 186.

    Google Scholar 

  96. Deane LM, Deane MP (1955) Observações preliminares sobre a importância comparativa do homem, do cão e da raposa (Lycalopex vetulus) como reservatório da Leishmania donovani em área endêmica de calazar no Ceará. Hospital, Rio de Janeiro 48:61–76.

    Google Scholar 

  97. Villela F, Pestana BR, Pessoa SB (1939) Presença de Leishmania braziliensis na mucosa nasal sem lesão aparente em casos recentes de leishmaniose cutânea. Hospital, Rio de Janeiro 16:953–956.

    Google Scholar 

  98. Marsden PD (1979) Leishmaniasis. N Engl J Med 300:350–352.

    Article  PubMed  CAS  Google Scholar 

  99. Kerdel-Vegas K (1982) American leishmaniasis. Int J Dermatol 21:291–303.

    Article  PubMed  CAS  Google Scholar 

  100. Pupo JA (1964) Estudo clínico de leishmaniose tegumentar americana (Leishmania braziliensis-Vianna 1911). Rev Hosp Clin Fac Med Univ São Paulo 1:113–164.

    Google Scholar 

  101. Guimarães NA, Silva YP (1957) Lesões ósseas da leishmaniose. An brasil derm sif 32:1–7.

    PubMed  Google Scholar 

  102. Furtado T, Barros J (1958) Lesiones osseas en 1a leishmaniosis tegumentar americana. Arch argent dermatol 8:279–284.

    Google Scholar 

  103. Dostrowsky A (1936) Relapses in cutaneous leishmaniasis. Ann Trop Med Parasitol 30:267–274.

    Google Scholar 

  104. Guerra MOP, Furtado T, Barros GC, Sersa PA, Daher VR (1985) Infecção subclínica na leishmaniose tegumentar americana. An bras Dermatol 60:365–369.

    Google Scholar 

  105. Costa JML, Sampaio RN, Tada MS, Almeida EA, Veiga EP, Magalhães AV, Marsden PD (1985) Furazolidone treatment of cutaneous leishmaniasis. Trans Roy Soc Trop Hyg 79:274.

    Article  CAS  Google Scholar 

  106. Furtado T (1982) American Leishmaniasis. Current status and management. In: Moschella SL (ed) Dermatology update. Elsevier, New York.

    Google Scholar 

  107. Neal RA, Croft SL, Nelson DJ (1985) Anti-leishmanial of allopurinol ribonucleoside and the related compounds, allopurinol, thiopurinol ribonucleoside, and of formycin B, sinefungin and the lepidine WR 6026. Trans Roy Soc Med Hyg 79:122–128.

    Article  CAS  Google Scholar 

  108. Weinrauch L, Livshin R, Even-Paz Z, El-On J (1983) Efficacy of ketoconazole in cutaneous leishmaniasis. Arch Dermatol Res 275:353–354.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dermatology Clinic, Faculty of Medicine, University of Minas Gerais, Belo Horizonte, Brazil

    T. Furtado (Chairman)

  2. Instituto de Biomedicina, Central University of Venezuela, Caracas, Venezuela

    M. Goihman-Yahr (Co-Chairman), F. J. Tapia, M. C. Bastardo de Albornoz, A. Bretaña, J. Pereira, B. San Martín, M. H. de Gómez, A. de Román, A. J. Rondón Lugo & J. Convit

  3. Department of Dermatology, Hannover University Medical School, Hannover, FR Germany

    S. Marghescu

  4. Department of Immunology, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil

    G. Grimaldi Jr.

  5. Division of Tropical Medicine, Harvard Medical School, Boston, Massachusetts, USA

    J. R. David

  6. Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA

    D. McMahon-Pratt

  7. Instituto Nacional de Tuberculosis y Hospital „Simón Bolívar“, Caracas, Venezuela

    A. Rothenberg, R. Rosquete, E. Avila-Millán, G. Istúriz, N. Viloria, N. Saavedra de Borges, M. Carrasquero & B. Pérez de Fernández

  8. Hospital del Tórax, Ciudad Bolívar, Venezuela

    I. Cabello de Brito

  9. Departamento Medicina Interna, Hospital Vargas, Caracas, Venezuela

    G. Urquiola

  10. University of Rio de Janeiro, Rio de Janeiro, Brazil

    A. Padilha-Gonçalves

  11. Dermatology Clinic, Faculty of Medicine, University of Minas Gerais, Belo Horizonte, Brazil

    E. C. S. Vale & M. Grossi Araújo

Authors
  1. T. Furtado
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  2. M. Goihman-Yahr
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  3. S. Marghescu
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  4. G. Grimaldi Jr.
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  5. J. R. David
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  6. D. McMahon-Pratt
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  7. A. Rothenberg
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  8. R. Rosquete
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  9. E. Avila-Millán
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  10. G. Istúriz
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  11. N. Viloria
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  12. N. Saavedra de Borges
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  13. M. Carrasquero
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  14. B. Pérez de Fernández
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  15. F. J. Tapia
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  16. M. C. Bastardo de Albornoz
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  17. A. Bretaña
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  18. I. Cabello de Brito
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  1. Universitäts-Hautklinik und Poliklinik, Klinikum Steglitz der Freien Universität, Hindenburgdamm 30, D-1000, Berlin 45, Federal Republic of Germany

    Constantin E. Orfanos (CMD — Scientific Secretariat), Rudolf Stadler (CMD — Scientific Secretariat) & Harald Gollnick (CMD — Scientific Secretariat) (CMD — Scientific Secretariat),  (CMD — Scientific Secretariat) &  (CMD — Scientific Secretariat)

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© 1988 Springer-Verlag Berlin Heidelberg

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Furtado, T. et al. (1988). Biology of Leishmania and Leishmaniasis. In: Orfanos, C.E., Stadler, R., Gollnick, H. (eds) Dermatology in Five Continents. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83360-1_87

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  • DOI: https://doi.org/10.1007/978-3-642-83360-1_87

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83362-5

  • Online ISBN: 978-3-642-83360-1

  • eBook Packages: Springer Book Archive

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