Abstract
Fetuin, an alpha 1-glycoprotein (MW : 48 kD) was firstly isolated from bovine foetal serum (4). Dziegielewska et al. (1) recently gave evidence that a fetuin-like antigen (FLA) was present in early human foetal samples but not later in gestation. We have shown that FLA was not detectable in normal human sera (< 5 μg)l) but was present at a concentration ranging from 10 to 80 μg/1 in a few disorders in which the immune System was involved and in sera of patients with tumours derived from the neutral crest or with nephroblastoma (2). In neurological disorders, FLA was found in sera from patients with multiple sclerosis (MS), Guillain-Barré Syndrome, neurosyphilis and peripheral, mainly diabetic, neuropathies, but was rarely detected in cerebrospinal fluid (2).
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References
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© 1987 Springer-Verlag Berlin Heidelberg
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Sindic, C.J.M., Chalon, M.P., Fagnart, O.C., Laterre, E.C. (1987). A Fetuin-like Antigen in MS Sera: An Immunosuppressive Factor?. In: Poeck, K., Hacke, W., Schneider, R. (eds) Neuroimmunologie Spinale Krankheiten Neuropsychologie Metabolische Enzephalopathien Neurologische Notfälle Interventionelle Neuroradiologie. Verhandlungen der Deutschen Gesellschaft für Neurologie, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83201-7_122
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DOI: https://doi.org/10.1007/978-3-642-83201-7_122
Publisher Name: Springer, Berlin, Heidelberg
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