Preliminary Results of a Randomized Study of Intrahepatic Infusion Versus Systemic Infusion of 5-Fluoro-2′ -deoxyuridine for Metastatic Colorectal Carcinoma

  • N. Kemeny
  • J. Daly
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 100)


Development of a totally implantable infusion pump produced a renewed interest in hepatic infusional therapy. An initial study employing this pump by Ensminger and associates and the continuous hepatic infusion of 5-fluoro-2′-deoxyuridine (FUdR) observed an 83% response rate [1]. However, further work with this method brought the mean response rate down to 59% (Table 1) [2], which, however, is still higher than the mean response rate obtained with systemic chemotherapy.


Hepatic Artery Systemic Group Extrahepatic Disease Liver Involvement Metastatic Colorectal Carcinoma 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1986

Authors and Affiliations

  • N. Kemeny
    • 1
  • J. Daly
    • 1
  1. 1.Solid Tumor Service, Department of MedicineMemorial Sloan-Kettering Cancer CenterUSA

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