Preliminary Results of a Randomized Study of Intrahepatic Infusion Versus Systemic Infusion of 5-Fluoro-2′ -deoxyuridine for Metastatic Colorectal Carcinoma
Development of a totally implantable infusion pump produced a renewed interest in hepatic infusional therapy. An initial study employing this pump by Ensminger and associates and the continuous hepatic infusion of 5-fluoro-2′-deoxyuridine (FUdR) observed an 83% response rate . However, further work with this method brought the mean response rate down to 59% (Table 1) , which, however, is still higher than the mean response rate obtained with systemic chemotherapy.
KeywordsHepatic Artery Systemic Group Extrahepatic Disease Liver Involvement Metastatic Colorectal Carcinoma
Unable to display preview. Download preview PDF.
- 1.Ensminger W, Niederhuber J, Gyves J, Thrall J, Cozzi E, Doan K (1982) Effective control of liver metastases from colon cancer with an implanted system for hepatic arterial chemotherapy. Proc ASCO 1: 94Google Scholar
- 4.Pettavel J, Morgenthaler F (1978) Protracted arterial chemotherapy of liver tumors: an experience of 107 cases over a 12-year period. In: Ariel IM (ed) Progress in clinical cancer. Grune and Stratton, New York, pp 217–233Google Scholar