Anaesthesia — Innovations in Management pp 123-131 | Cite as
The Ability of Perfluorochemicals to Provide Microcirculatory Oxygenation
Chapter
Abstract
Perfluorochemicals have recently become available in the form of oxygen-carrying plasma substitutes containing 20% or 35% (weight by volume) of perfluorocarbons respectively. These preparations are known as Fluosol-DA 20% and Fluosol-DA 35%. The composition of these products is shown in Table 1. They have a number of interesting properties in relation to their oxygen-carrying ability and their ability to penetrate the microcirculation. This paper will discuss some of these properties.
Keywords
Shear Rate Left Anterior Descend Dextran Solution Plasma Substitute Total Body Oxygen
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Preview
Unable to display preview. Download preview PDF.
References
- Bouchardy B, Manjo G (1974) Histopathology of early myocardial infarcts. A new approach. Am J Pathol 74:301PubMedGoogle Scholar
- Erdmann W, Vogel HR (1973) Die Sauerstoffversorgung des Gehirns. Bundesärzteblatt 8Google Scholar
- Faithfull NS, Erdmann W, Fennema M (1983a) Oxygen supply to the myocardium. In: Proceedings of the International Society for Oxygen Transport to Tissue. Rushton, Los Angeles 16–19 August 1983Google Scholar
- Faithfull NS, Fennema M, Erdmann W, Lapin R, Smith AR, Van Alphen W, Essed CE, Trouwborst A (1983b) Tissue oxygenation by fluorocarbons. In: Proceedings of the International Society for Oxygen Transport to Tissue. Rushton, Los Angeles 16–19 August 1983Google Scholar
- Faithfull NS, Fennema M, Essed CE, Erdmann W, Jeekel H, Lapin R (1983c) Collateral oxygenation of the ischemic myocardium: The effect of viscosity and oxygen carrying fluorocarbons. In: Advances in blood substitute research. Liss New York, p 229Google Scholar
- Goslinga H (1982) The viscosity of blood. An experimental study into the effects of alterations in blood viscosity during shock. PhD Thesis, University of Utrecht. Drukkerij Elinkwijk, UtrechtGoogle Scholar
- Naito R, Yokoyama K (1978) Perfluorochemical blood substitutes. Green Cross, OsakaGoogle Scholar
- Pryce-Jones C (1933) Blood pictures: an introduction to clinical haematology. Williams and Wilkins, BaltimoreGoogle Scholar
- Schmid-Schönbein H, Weiss J, Ludwig H (1973) A simple method for measuring red cell deformability in models of the microcirculation. Blut 16:369CrossRefGoogle Scholar
- Yokoyama K, Suzuki A, Utsumi I, Naito R (1974) Determination of particle size distribution fluorocarbon emulsion by means of centrifugal sedimentation. Chem Pharm Bull (Tokyo) 22:2966CrossRefGoogle Scholar
Copyright information
© Springer-Verlag Berlin, Heidelberg 1985