Abstract
The introduction of nuclear magnetic resonance (NMR) into medicine [1] initially created hopes that this totally noninvasive imaging modality would be able to differentiate clearly between healthy and pathological tissue on the basis of T1 and T2 signals [2]. As originally conceived, however, these hopes were overly optimistic as they assumed that parameters characterizing processes on a nuclear or molecular scale could provide a sensitive and specific means of characterizing disease processes which, although ultimately based on molecular derangements, manifest themselves on a micro- and macrostructural and functional level. Thus MRI techniques geared towards elucidating these pathophysiological processes had to be developed.
Keywords
Contrast Agent Blood Volume Perfusion Image Cerebral Blood Volume Blood Oxygenation Level DependentPreview
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References
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