Measuring Cellular Traction Forces with Micromachined Substrates
Chapter
Abstract
The ability to pattern silicon substrates revolutionized electronics by miniaturizing circuit components 40 years ago. The processes defined by this field have been extended within the past 25 years to make three dimensional silicon structures such as levers, diaphragms, valves, and gears which are the basis of a variety of miniature mechanical devices. These devices have a wide range of commercial applications, from accelerometers used for air bag release, to print heads for ink jet printers, pressure sensors for cardiovascular catheters, and even complete miniaturized gas chromatographs. More recently, micromachining has found applications in tissue engineering and fundamental studies on cell motility and guidance. This chapter will describe micromachining, its application in studying cell motility, and a new micro-machined device that we are using to measure sub-cellular traction forces.
Keywords
Traction Force Polycrystalline Silicon Micro Electrode Array North Carolina 27710 Neuron Growth Cone
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