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Funktion, Lokalisation und Regulation des D3-Rezeptors: Relevanz für antipsychotische Mechanismen

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Schizophrenie

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Zusammenfassung

Mit molekularbiologischen Techniken konnten in jüngerer Zeit 5 verschiedene Gene identifiziert werden, die für Dopaminrezeptoren (DA-Rezeptoren) kodieren (Schwartz et al. 1992; Sibley u. Monsma 1992). Diese Rezeptoren lassen sich in D1- und D2-artige Unterfamilien einteilen, welche sich mehr oder weniger mit den früher in klassischen pharmakologischen Studien definierten D1- und D2-Rezeptoren decken (Spano et al. 1978; Kebabian u. Calne 1979). D1-artige Rezeptoren, z. B. D1- und D5-Rezeptoren, aktivieren die Bildung von zyklischem Adenosinmonophosphat (cAMP) und weisen eine hohe Affinität für „D1-selektive“ Agonisten und Antagonisten auf. D2-artige Rezeptoren, z. B. D2-, D3- und D4-Rezeptoren, verhalten sich wie hemmende Rezeptoren, indem sie nämlich im Fall der D2-und D4-Rezeptoren die Bildung von cAMP verhindern (Neve et al. 1989; Vallar et al. 1990, 1991; Cohen et al. 1993) und binden bereits früher identifizierte „D2-selektive“ Substanzen wie Anti-Parkinsonmittel und Antipsychotika.

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Authors
  1. P. Sokoloff
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  2. J. Diaz
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  3. M.-P. Martres
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  4. D. Levesque
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  5. C. Pilon
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  6. V. Dimitriadou
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  7. N. Griffon
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  8. C. H. Lammers
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  9. J.-C. Schwartz
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Editors and Affiliations

  1. Dept. P & The Research Institute of Biological Psychiatry, Copenhagen Hospital Corporation, St. Hans Hospital, DK-4000, Roskilde, Dänemark

    Jes Gerlach M. D.

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Sokoloff, P. et al. (1995). Funktion, Lokalisation und Regulation des D3-Rezeptors: Relevanz für antipsychotische Mechanismen. In: Gerlach, J. (eds) Schizophrenie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79738-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-79738-5_2

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