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Sinorphan Improves Cardiac Structure and Function in Aged Stroke-Prone Spontaneously Hypertensive Rats

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Experimental Hypertension and Therapeutic Progress: Vasodilation and Beyond

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Abstract

Inhibition of atrial natriuretic peptide (ANP) degradation by enkephalinase is known to increase endogenous ANP levels and to induce similar functional effects as administration of exogenous ANP. The influence of this principle on cardiac function in rats with hypertension-induced heart failure was investigated.

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Author information

Authors and Affiliations

  1. Cardiovascular and Arteriosclerosis Research, Bayer AG, 42096, Wuppertal, Germany

    Andreas M. Knorr, Claudia Hirth-Dietrich, Johannes-Peter Stasch & Stanislav Kazda

Authors
  1. Andreas M. Knorr
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  2. Claudia Hirth-Dietrich
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  3. Johannes-Peter Stasch
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  4. Stanislav Kazda
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Editor information

Editors and Affiliations

  1. Cardiovascular and Arteriosclerosis Research, Bayer AG, Aprather Weg 18a, 42096, Wuppertal, Germany

    Bernward Garthoff DVM  & Andreas M. Knorr Ph.D.  & 

  2. International Research Pharma, Bayer AG, Aprather Weg 18a, 42096, Wuppertal, Germany

    Wolf-Dieter Busse Ph.D. (Professor) (Professor)

  3. Coordination International Research, Bayer AG, Aprather Weg 18a, 42096, Wuppertal, Germany

    Friedel Seuter Ph.D.

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© 1995 Springer-Verlag Berlin Heidelberg

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Knorr, A.M., Hirth-Dietrich, C., Stasch, JP., Kazda, S. (1995). Sinorphan Improves Cardiac Structure and Function in Aged Stroke-Prone Spontaneously Hypertensive Rats. In: Garthoff, B., Knorr, A.M., Busse, WD., Seuter, F. (eds) Experimental Hypertension and Therapeutic Progress: Vasodilation and Beyond. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79338-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-79338-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58545-9

  • Online ISBN: 978-3-642-79338-7

  • eBook Packages: Springer Book Archive

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